AP-4-Associated Hereditary Spastic Paraplegia

Summarized by Plex Health
Last Updated: 06 May 2022

AP-4-associated hereditary spastic paraplegia is a group of slowly-progressing neurodegenerative disorders that typically present with global developing hold-up, modest to serious intellectual special needs, impaired/absent speech, small head size, seizures, and progressive motor symptoms. Low muscle mass tone in early stage develops into high muscular tissue tone, resulting in spasticity of the legs that leads to the failure to stroll and wheelchair reliance. Most children with AP-4-associated HSP have: a saggy appearance in infancy as a result of low muscular tissue tone; increasing spasticity and paralysis in the lower arm or legs starting in very early childhood years; delayed motor growth; bad or missing speech development; moderate to serious intellectual disability; microcephaly; seizures consisting of constant seizures in the setting of fever.

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

** If you believe that content on the Plex is summarised improperly, please, contact us, and we will get rid of it quickly; please, send an email with a brief explanation.

*** If you want us to remove all links leading to your domain from Plex.page and never use your website as a source of the "Online Knowledge", please contact us using a corporate email and we will remove everything in 10 business days.


Plex Page is a Biology & Health Sciences "Online Knowledge Base," where a machine summarizes all the summaries.