Abiraterone
Summarized by Plex Health
Last Updated: 02 May 2022
"sarcopenia and change in body composition following maximal androgen suppression with abiraterone in men with castration-resistant prostate cancer.", by Pezaro C, Mukherji D, Tunariu N, Cassidy AM, Omlin A, Bianchini D, Seed G, Reid AH, Olmos D, de Bono JS, Attard G. fig2: Analysis of body composition using OsiriX software: (A) total (visceral and subcutaneous) and visceral fat analysis at baseline, (B) after abiraterone and (A) (C) after abiraterone plus dexamethasone; (A+D) muscle analysis, including psoas, paravertebral...
Abiraterone acetate, the active component of abiraterone acetate tablets USP is the acetyl ester of abiraterone. Each abiraterone acetate tablet USP includes 250 mg of abiraterone acetate. Abiraterone is designated chemically as 17-androsta-5,16-dien-3 -yl acetate and its framework is: Abiraterone acetate is a white to off-white, non-hygroscopic, crystalline powder. Abiraterone acetate tablets USP are available in 250 mg uncoated tablets with the complying with inactive components: 250 mg uncoated tablets: colloidal silicon dioxide, croscarmellose sodium, lactose monohydrate, magnesium stearate, microcrystalline povidone, cellulose, and sodium lauryl sulphate. abiraterone is used in men whose prostate cancer can not be treated with surgical procedure or other medications. If a woman is subjected to it during pregnancy, abiraterone can harm an expected child. Use efficient birth control if your sex partner is pregnant or able to get pregnant. Your high blood pressure will require to be inspected frequently, and you may need regular blood tests. Abiraterone is used in combination with methylprednisolone to deal with patients with metastatic castration-resistant prostate cancer. This medicine is available only with your physician's prescription.
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Sources:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=32f6b83d-c743-4934-9a20-1b5bf9f4e...
https://www.drugs.com/abiraterone.html
https://www.mayoclinic.org/drugs-supplements/abiraterone-oral-route/description/drg-204438...
PubChem - CovalentUnitCount
(Table source)| CID | MolecularFormula | MolecularWeight | CanonicalSMILES | IsomericSMILES | InChI | InChIKey | IUPACName | XLogP | ExactMass | MonoisotopicMass | TPSA | Complexity | Charge | HBondDonorCount | HBondAcceptorCount | RotatableBondCount | HeavyAtomCount | IsotopeAtomCount | AtomStereoCount | DefinedAtomStereoCount | UndefinedAtomStereoCount | BondStereoCount | DefinedBondStereoCount | UndefinedBondStereoCount | CovalentUnitCount |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 132971 | C24H31NO | 349.5 | CC12CCC(CC1=CCC3C2CCC4(C3CC=C4C5=CN=CC=C5)C)O | C[[email protected]]12CC[[email protected]@H](CC1=CC[[email protected]@H]3[[email protected]@H]2CC[[email protected]]4([[email protected]]3CC=C4C5=CN=CC=C5)C)O | InChI=1S/C24H31NO/c1-23-11-9-18(26)14-17(23)5-6-19-21-8-7-20(16-4-3-13-25-15-16)24(21,2)12-10-22(19)23/h3-5,7,13,15,18-19,21-22,26H,6,8-12,14H2,1-2H3/t18-,19-,21-,22-,23-,24+/m0/s1 | GZOSMCIZMLWJML-VJLLXTKPSA-N | (3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-pyridin-3-yl-2,3,4,7,8,9,11,12,14,15-decahydro-1H-cyclopenta[a]phenanthren-3-ol | 4.6 | 349.240564612 | 349.240564612 | 33.1 | 636 | 0 | 1 | 2 | 1 | 26 | 0 | 6 | 6 | 0 | 0 | 0 | 0 | 1 |
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