Acute Promyelocytic Leukemia

Summarized by Plex Health
Last Updated: 02 May 2022
acute promyelocytic leukemia, hypogranular variant: a rare presentation. "acute promyelocytic leukemia, hypogranular variant: a rare presentation.", by Akhtar K, Ahmad S, Sherwani RK. F3: Acute promyelocytic leukemia: FISH technique shows chromosomal translocation, t(15;17)....

Acute promyelocytic leukemia is a blood cancer identified by a significant increase in a type of white blood cells called promyelocytes, a type of premature white blood cell. A decreased number of red cell can lead to pallor and exhaustion, while a decreased number of practical white blood cells incline affected people to infections. Circulating blood cells are formed in a region in the middle of large bones called the bone marrow and are all stemmed from a primitive type of cell referred to as the hematopoietic stem cell. Hematopoiesis refers to the process of development of blood cells from hematopoietic stem cells. The 2 major family trees of blood cells are the myeloid and lymphoid cells. Research that elucidated the molecular mechanisms by which APL develops caused the growth of ATRA, an oral drug that particularly targets the genetic defects in APL. In acute promyelocytic leukemia, premature white blood cells called promyelocytes accumulate in the bone marrow. Since of the low number of platelets in the blood and due to the fact that the malignant cells release substances that cause extreme blood loss, the abnormal blood loss and wounding occur in part. Acute promyelocytic leukemia is usually identified around age 40, although it can be diagnosed at any age. APL is a subtype of the cancer acute myeloid leukemia. If you have been told that your child might have APL, the child needs medical attention right away. Therapy of APL differs from treatments for other forms of leukemia. Many children with APL need admission to the extensive care unit due to problems that occur when therapy begins. Future researches prepare to use arsenic trioxide throughout induction for a selected group of patients. The combination is used to remove any cells that may have been inactive throughout the first phase however can begin to grow and cause APL to return. If APL returns, most children can be placed into a 2nd remission making use of arsenic trioxide, alone or integrated with radiation treatment and stem cell transplantation.

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