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Adefovir

Summarized by Plex Health
Last Updated: 02 May 2022
differential binding of tenofovir and adefovir to reverse transcriptase of hepatitis b virus. "differential binding of tenofovir and adefovir to reverse transcriptase of hepatitis b virus.", by van Hemert FJ, Berkhout B, Zaaijer HL. pone-0106324-g005: Sequential docking of dATP, dGTP, and adefovir (left panel) or tenofovir (right panel) into the HBV-RT structure carrying S78T & A181V amino acid replacements.T78 and V181 are in hot-pink. YMDD is indicated by space-filling....

Adefovir is an antiviral medication that is used to treat chronic hepatitis B in adults and children a minimum of 12 years of ages. Adefovir is not a remedy for chronic hepatitis B. Adefovir may additionally be used for purposes not provided in this medication guide. You might require to be tested for HIV before you begin taking adefovir. Tell your physician if you have been exposed to HIV, or if you have untreated HIV or AIDS. Adefovir can harm your kidneys, especially if you already have kidney issues or take specific medications. You may develop lactic acidosis, a dangerous build-up of lactic acid in your blood. Liver disease B might become active or become worse after you stop using adefovir. If you are allergic to it, you should not take adefovir. If you medication that contains tenofovir, you must not take adefovir. Taking medications to deal with persistent liver disease B can cause HIV infection to end up being resistant to the basic HIV and AIDS medicines. You may need to be tested for HIV before you start taking adefovir. You may develop lactic acidosis, unsafe build-up of lactic acid in your blood. Your name might be detailed on a pregnancy registry to track the impacts of adefovir on the infant if you are pregnant. Liver disease B may come to be active or become worse in the months after you stop making use of adefovir. You might require regular liver function tests while utilizing this medicine and for a number of months after your last dose. Take the medication as quickly as you can, however skip the missed out on dosage if it is nearly time for your next dose.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
60172C8H12N5O4P273.19C1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)NC1=NC(=C2C(=N1)N(C=N2)CCOCP(=O)(O)O)NInChI=1S/C8H12N5O4P/c9-7-6-8(11-3-10-7)13(4-12-6)1-2-17-5-18(14,15)16/h3-4H,1-2,5H2,(H2,9,10,11)(H2,14,15,16)SUPKOOSCJHTBAH-UHFFFAOYSA-N2-(6-aminopurin-9-yl)ethoxymethylphosphonic acid-2273.06269088273.0626908813632703851800000001
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