Summarized by Plex Health
Last Updated: 02 May 2022
afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting atp binding cassette subfamily b member 1. "afatinib reverses multidrug resistance in ovarian cancer via dually inhibiting atp binding cassette subfamily b member 1.", by Wang SQ, Liu ST, Zhao BX, Yang FH, Wang YT, Liang QY, Sun YB, Liu Y, Song ZH, Cai Y, Li GF. F5: Afatinib attenuated the expression of ABCB1 by inhibiting its transcription via down-regulation of PI3K/AKT and MAPK/p38-dependent activation of NF-κBA. Effects of afatinib on the expression of correlated proteins. A2780T cells were treated with 0.625–2.5...

Afatinib is a cancer drug used to treat non-small cell lung cancer that is EGFR -positive, which means that it is triggered by an abnormal EGFR genetics or genes. The EGFR protein is found on the surface area of cells and helps them to grow, yet when the gene for EGFR is abnormal or malfunctioning cells can grow out of control creating cancer. Afatinib helps to reduce the spread or quit of cancer and may help people with EGFR-positive NSCLC live longer. It is not known if afatinib is risk-free and efficient in dealing with people with lung cancer that has resistant abnormal EGFR genetics. Miss the dose and just take your next dosage at your normal time if it is within 12 hours of your following dose. Do not take 2 doses of afatinib at the same time. afatinib can make your skin conscious sunlight. Use sunscreen and put on a hat and garments that cover your skin if you have to be in sunshine throughout treatment with afatinib.

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

** If you believe that content on the Plex is summarised improperly, please, contact us, and we will get rid of it quickly; please, send an email with a brief explanation.

PubChem - CovalentUnitCount

(Table source)
10184653C24H25ClFN5O3485.9CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[[email protected]]4CCOC4InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1ULXXDDBFHOBEHA-CWDCEQMOSA-N(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide3.6485.1629955485.162995588.670202883401101101
*** If you want us to remove all links leading to your domain from and never use your website as a source of the "Online Knowledge", please contact us using a corporate email and we will remove everything in 10 business days.


Plex Page is a Biology & Health Sciences "Online Knowledge Base," where a machine summarizes all the summaries.