Alendronate

Summarized by Plex Health
Last Updated: 02 May 2022
effect of alendronate sodium on the expression of mesenchymal-epithelial transition markers in mice with liver fibrosis. "effect of alendronate sodium on the expression of mesenchymal-epithelial transition markers in mice with liver fibrosis.", by Bi WR, Jin CX, Xu GT, Yang CQ. f5-etm-05-01-0247: Protein expression of E-cadherin and α-SMA in mouse hepatic tissue (immunofluorescence method). (A–D) protein expression of E-cadherin; (E–H) protein expression of α-SMA; (A and E) alendronate sodium control group; (B,C,D,F,G and H) alendronate sodium-treated...

Alendronate sodium is a bisphosphonate that functions as a specific inhibitor of osteoclast-mediated bone resorption. Bisphosphonates are synthetic analogs of pyrophosphate that bind to the hydroxyapatite found in bone. Alendronate sodium is chemically defined as bisphosphonic acid monosodium salt trihydrate. The empirical formula of alendronate salt is C 4H 12NNaO 7P 2 3H 2O and its formula weight is 325. 12. The structural formula is: Alendronate sodium is a white, crystalline, nonhygroscopic powder. It is soluble in water, very somewhat soluble in alcohol, and practically insoluble in chloroform. Alendronate sodium tablets, USP for oral administration include 6. 53, 13. 06, 45. 69 or 91. 37 mg of alendronate monosodium salt trihydrate, which is the molar equivalent of 5, 10, 35 and 70 mg, respectively, of free acid, and the complying with non-active ingredients: microcrystalline cellulose, croscarmellose salt, and magnesium stearate. alendronate is for use when you have a high risk of bone fracture as a result of osteoporosis. You need to not take alendronate if you have problems with your esophagus, or low levels of calcium in your blood. Quit utilizing alendronate and call your medical professional simultaneously if you have breast pain, new or aggravating heartburn, or pain when swallowing. This medication might cause jaw bone issues. Stop using the medicine and inform your doctor right away if you conceive. If you take alendronate only once each week, take it on the same day each week and always first point in the morning. The esophagus is television that carries food and drink from your mouth to your stomach when you swallow. Swallow the tablet whole with a large glass of ordinary water only. Do not take the medication while you are still in bed, and do not take at bedtime; Wait at least 30 mins after you ingest the tablet prior to you drink or consume anything or take any other medicines; Do not relax for at least 30 minutes after taking this medicine, and do not relax prior to you have eaten some food. Your medical professional might order calcium and vitamin D supplements if your body is not getting enough calcium from your diet plan.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
13688298C4H9NNa4O7P2337.02C(CC(O)(P(=O)([O-])[O-])P(=O)([O-])[O-])CN.[Na+].[Na+].[Na+].[Na+]C(CC(O)(P(=O)([O-])[O-])P(=O)([O-])[O-])CN.[Na+].[Na+].[Na+].[Na+]InChI=1S/C4H13NO7P2.4Na/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;;;;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);;;;/q;4*+1/p-4YSHCAWNMHTVFQX-UHFFFAOYSA-Jtetrasodium;4-amino-1,1-diphosphonatobutan-1-ol336.94450275336.9445027517323402831800000005
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