Aliskiren

Summarized by Plex Health
Last Updated: 02 May 2022
direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats. "direct renin inhibition with aliskiren protects against myocardial ischemia/reperfusion injury by activating nitric oxide synthase signaling in spontaneously hypertensive rats.", by Zhang W, Han Y, Meng G, Bai W, Xie L, Lu H, Shao Y, Wei L, Pan S, Zhou S, Chen Q, Ferro A, Ji Y. fig06: The effect of aliskiren on both systemic oxidative stress and myocardial superoxide anion generation, in SHR following I/R. A, Myocardial cGMP, an index of bioactive NO, was reduced by I/R in SHR, and this...

Aliskiren hemifumarate is chemically called -N5amino-4hydroxy- 2,7-diisopropyl-8 [4-methoxy-3phenyl] -octanamide hemifumarate and its structural formula is: Molecular formula: C30H53N3O6 0. 5 C4H4O4 Aliskiren hemifumarate is a white to slightly yellowish crystalline powder with a molecular weight of 609. 8. High blood pressure adds to the work of the heart and arteries. If it proceeds for a lengthy time, the heart and arteries may not function correctly. This can harm the blood vessels of the brain, heart, and kidneys, leading to a stroke, cardiac arrest, or kidney failure. Lowering high blood pressure will decrease the risk of strokes and cardiac arrest. Aliskiren is a renin inhibitor. It works by obstructing an enzyme in the body that is essential to create a substance that causes blood vessels to tighten up. Because of this, the capillary relax and this decreases the blood pressure. When the high blood pressure is lowered, the amount of blood and oxygen that most likely to the heart is increased. This medication is offered only with your doctor's prescription.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
5493444C30H53N3O6551.8CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)NCC(C)[[email protected]@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[[email protected]@H]([[email protected]](C[[email protected]@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)NInChI=1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1UXOWGYHJODZGMF-QORCZRPOSA-N(2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide3.5551.39343642551.39343642146717047193904400001
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