Alogliptin

Summarized by Plex Health
Last Updated: 02 May 2022
enhancing pancreatic beta-cell regeneration in vivo with pioglitazone and alogliptin. "enhancing pancreatic beta-cell regeneration in vivo with pioglitazone and alogliptin.", by Yin H, Park SY, Wang XJ, Misawa R, Grossman EJ, Tao J, Zhong R, Witkowski P, Bell GI, Chong AS. pone-0065777-g003: Effect of alogliptin alone or in combination with pioglitazone on endogenous beta-cell regeneration.Bioluminescent signal (Photons/sec) from endogenous pancreas of albino MIP-luc mice treated with (a) aloglipin alone (Alog 15 or 45 mg/kg/day; 5X/week) or...

Alogliptin is used together with diet and workout to boost blood glucose control in adults with type 2 diabetes mellitus. alogliptin is except treating type 1 diabetes. Alogliptin is sometimes used in combination with other diabetes mellitus medications. Alogliptin may be used for objectives not detailed in this medicine overview. Alogliptin can cause serious side effects on your heart or pancreatic, particularly if you have ever had similar troubles, or if you have kidney or liver disease. Your blood glucose will require to be checked commonly, and you might need other blood tests at your doctor's workplace. Your doctor might suggest a glucagon injection package in situation you have severe hypoglycemia. Type 2 diabetes mellitus is a condition where the body does not make sufficient insulin, or the insulin that it makes does not work effectively. Alogliptin is recommended for people who still have high blood sugar, although they have a sensible diet regimen and exercise regularly. It additionally comes as tablets having a blend of alogliptin and another diabetic issues medication called metformin. You require to take it daily to make certain your blood sugar level remains as secure as possible. You take alogliptin once daily. One of the most common side effects of alogliptin are headaches, acid indigestion, diarrhea and skin rashes. Chemically, alogliptin is prepared as a benzoate salt, which is identified as 2-benzonitrile monobenzoate. The structural formula is: Alogliptin benzoate is a white to beige crystalline powder including one asymmetric carbon in the aminopiperidine moiety. Each NESINA tablet includes 34 mg, 17 mg or 8. 5 mg alogliptin benzoate, which is equal to 25 mg, 12. 5 mg or 6. 25 mg, respectively, of alogliptin and the following inactive ingredients: mannitol, microcrystalline cellulose, hydroxypropyl cellulose, croscarmellose sodium and magnesium stearate.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
11450633C18H21N5O2339.4CN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCCC(C3)NCN1C(=O)C=C(N(C1=O)CC2=CC=CC=C2C#N)N3CCC[[email protected]](C3)NInChI=1S/C18H21N5O2/c1-21-17(24)9-16(22-8-4-7-15(20)12-22)23(18(21)25)11-14-6-3-2-5-13(14)10-19/h2-3,5-6,9,15H,4,7-8,11-12,20H2,1H3/t15-/m1/s1ZSBOMTDTBDDKMP-OAHLLOKOSA-N2-[[6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile0.6339.16952493339.1695249393.762201532501100001
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