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Alpelisib

Summarized by Plex Health
Last Updated: 02 May 2022

Alpelisib is used in men and postmenopausal women with HR-positive, HER2-negative breast cancer that is advanced or has infected other parts of the body. Alpelisib is used only if your cancer has a specific hereditary marker. Alpelisib is for use only in women who can no longer get pregnant, you might require to have a negative pregnancy test prior to starting this therapy. If you have diarrhea while taking alpelisib: start taking anti-diarrhea medicine such as loperamide to quickly deal with looseness of the bowels. Your blood sugar level will require to be inspected frequently, and you might need other blood tests at your doctor's workplace. Keep each tablet computer in the sore pack until you are ready to take one. Alpelisib is additionally being studied in the treatment of other types of cancer. Definition from the NCI Drug Dictionary, Detailed scientific meaning and other names for this drug. If they can assist treat or prevent problems other than the ones they are approved for, drugs are usually researched to discover out. This patient details sheet uses only to accepted uses of the medication. Nonetheless, much of the details may also put on unapproved uses that are being studied. Targeted Cancer Therapies. The molecular formula for alpelisib is C19H22F3N5O2S and the relative molecular mass is 441. 47 g/mol. The chemical structure of alpelisib is revealed listed below: PIQRAY film-coated tablets are provided for oral administration with three strengths that contain 50 mg, 150 mg and 200 mg of alpelisib. The tablets contain hypromellose, magnesium stearate, mannitol, microcrystalline cellulose, and salt starch glycolate. The film-coating includes hypromellose, iron oxide black, iron oxide red, macrogol/polyethylene glycol 4000, talc, and titanium dioxide.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
56649450C19H22F3N5O2S441.5CC1=C(SC(=N1)NC(=O)N2CCCC2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)FCC1=C(SC(=N1)NC(=O)N2CCC[[email protected]]2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)FInChI=1S/C19H22F3N5O2S/c1-10-14(11-6-7-24-13(9-11)18(2,3)19(20,21)22)30-16(25-10)26-17(29)27-8-4-5-12(27)15(23)28/h6-7,9,12H,4-5,8H2,1-3H3,(H2,23,28)(H,25,26,29)/t12-/m0/s1STUWGJZDJHPWGZ-LBPRGKRZSA-N(2S)-1-N-[4-methyl-5-[2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridin-4-yl]-1,3-thiazol-2-yl]pyrrolidine-1,2-dicarboxamide3.2441.14463062441.1446306212966302843001100001
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