Alpers-Huttenlocher Syndrome

Summarized by Plex Health
Last Updated: 02 May 2022

Alpers-Huttenlocher syndrome is just one of the most serious of a group of problems called the POLG-related disorders. Alpers-Huttenlocher syndrome typically ends up being apparent in children in between ages 2 and 4. People with Alpers-Huttenlocher syndrome usually have added symptoms and signs. Furthermore, affected people might develop weak muscle tone that gets worse until they lose the ability to control their muscle mass and movement. Some people with Alpers-Huttenlocher syndrome lose the ability to walk, rest, or feed themselves. Other movement-related symptoms in affected people can consist of involuntary muscle mass twitches, uncontrollable motions of the arm or legs, or a pattern of movement abnormalities referred to as parkinsonism. Affected individuals might have other brain-related signs and symptoms. Furthermore, people with this condition may have decreased brain function that is demonstrated as drowsiness, inability to concentrate, irritability, or loss of language abilities or memory. People with Alpers-Huttenlocher syndrome can survive from a couple of months to greater than 10 years after the condition first shows up.

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