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Amoxicillin 250mg Capsules

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Last Updated: 18 January 2022

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General | Latest Info

Amoxicillin is a broad - spectrum antibiotic prescribed for treatment of bacterial infections. It may also be effective against infections found in the ear, urinary tract, upper respiratory tract and on skin. Amoxicillin has also been prescribed for treatment of dental infections. Side effects are more likely to occur in those who have previously demonstrated hypersensitivity to penicillins and in those with a history of allergies asthma, hay fever, or urticaria. Some possible side effects include lack of appetite, vomiting, drooling or diarrhea. This medication may interact with allopurinol or probenecid. Other medications may also interact with Amoxicillin. Before giving Amoxicillin, talk to your veterinarian about any prescription or over - counter medicines, vitamins, minerals and herbal products your pet is currently taking. Consult your veterinarian before using this medication if your pet is currently taking vitamins, supplements, bacteriostatic antibiotics, probenecid or methotrexate, as interactions may occur. Amoxicillin is a broad - spectrum antibiotic. Antibiotics are drugs which kill or stop the growth of bacteria. Amoxicillin is very safe and is often prescribed for infections while waiting for laboratory results. Amoxicillin is very useful for treatment and prevention of a wide variety of bacterial infections. Treats ear infections, urinary infections and skin infections. Also effective against upper respiratory, bladder and dental infections. Give this medication exactly as directed by your veterinarian. Amoxicillin can be given with or without food. Give all of Amoxicillin even if your pet appears to be better. Symptoms may improve before the infection is completely treat. Amoxicillin blocks bacteria from making cell wall. As a result, bacteria usually die. Amoxicillin is absorbed well from the digestive system and is distributed to many body tissues, making it effective against infections in multiple organs. It is active against many different types of bacteria. It is usually given two to three times a day for a number of days. If doses are missed or the entire treatment regimen is not complete, infection could recur or worsen. Consult your veterinarian if an animal's condition does not improve or worsens after beginning treatment with Amoxicillin.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Interactions

The effects of some drugs can change if you take other drugs or herbal products at the same time. This can increase your risk for serious side effects or may cause your medications not to work correctly. These drug interactions are possible, but do not always occur. Your doctor or pharmacist can often prevent or manage interactions by changing how you use your medications or by close monitoring. To help your doctor and pharmacist give you the best care, be sure to tell your doctor and pharmacist about all products you use before starting treatment with this product. While using this product, do not start, stop, or change dosage of any other medicines you are using without your doctor's approval. The product that may interact with this drug is: methotrexate. Amoxicillin may cause false positive results with certain diabetic urine testing products. This drug may also affect the results of certain lab tests. Make sure laboratory personnel and your doctors know you use this drug. This document does not contain all possible drug interactions. Keep a list of all the products you use. Share this list with your doctor and pharmacist to lessen your risk for serious medication problems.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Side Effects

Amoxicillin is one of the most commonly prescribed antibiotics. It is similar to penicillin and can kill a wide variety of bacteria including Streptococcus species, Listeria monocytegenes, Enterococcus, Haemophilus influenzae, some E. Coli, Actinomyces, Clostridial species, Shigella, Salmonella, and Corynebacteria. This antibiotic belongs to a specific class of drugs called beta - lactams. Beta - lactam antibiotics such as amoxicillin work by binding proteins and inhibiting certain processes in bacterial cells. This causes cell walls to break down and destroy bacteria, process called bactericidal killing. Amoxicillin begins TO work quickly after a patient takes it, and it reaches peak blood concentrations in about one or two hours, according TO drugs label. However, improvement in symptoms will take longer. People should see their symptoms improve within 72 hours, or about three days, but could see improvement as early as 24 hours, according to TO license pharmacist Brian Staiger. If patients do see improvement in three days, they should speak TO their medical provider about other treatment options.


Serious side effects

Serious side effects are rare and happen in less than 1 in 1 000 people. Diarrhoea that contains blood or mucus. If you have severe diarrhoea for more than 4 days, you should also speak to a doctor about pale poo with dark pee, yellowing of skin or whites of your eyes, bruising or skin discolouration, joint or muscle pain that comes on after 2 days of taking medicine, skin rash with circular red patches some of these serious side effects can happen up to 2 months after finishing amoxicillin.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

CLINICAL PHARMACOLOGY

Enterococcus

MIC (mcg/mL)Interpretation
8Susceptible (S)
16Resistant (R)
Staphylococcus a
MIC (mcg/mL)Interpretation
0.25Susceptible (S)
0.5Resistant (R)

Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after oral ADMINISTRATION. The effect of food on absorption of amoxicillin from tablets and suspension of amoxicillin has been partially investigate. 400 mg and 875 mg formulations have been studied ONLY when administered at the start of light meal. However, food effect STUDIES have not been performed with 200 mg and 500 mg formulations. Amoxicillin diffuses readily into most body tissues and fluids, with the exception of brain and spinal fluid, except when meninges are inflame. The half - life of amoxicillin is 61. 3 minutes. Most amoxicillin is excreted unchanged in urine; its excretion can be delayed by concurrent ADMINISTRATION of probenecid. In blood serum, amoxicillin is approximately 20% protein - bound. Orally administered doses of 250 mg and 500 mg amoxicillin capsules result in average peak blood levels 1 to 2 hours after ADMINISTRATION in range of 3. 5 mcg / mL to 5. 0 mcg / mL and 5. 5 mcg / mL to 7. 5 mcg / mL, respectively. Mean amoxicillin pharmacokinetic parameters from an open, two - part, single - dose crossover bioequivalence study in 27 adults comparing 875 mg of amoxicillin with 875 mg of amoxicillin and clavulanate potassium show that 875 mg tablet of amoxicillin produces AUC O - of 35. 4 8. 1 mcghr / mL and C max of 13. 8 4. 1 mcg / mL. Dosing was at the start of a light meal following an overnight fast. Orally administered doses of amoxicillin suspension, 125 mg / 5 mL and 250 mg / 5 mL, result in average peak blood levels 1 to 2 hours after ADMINISTRATION in range of 1. 5 mcg / mL to 3. 0 mcg / mL and 3. 5 mcg / mL to 5. 0 mcg / mL, respectively. Oral ADMINISTRATION of single doses of 400 mg chewable tablets and 400 mg / 5 mL suspension of amoxicillin to 24 adult volunteers yielded comparable pharmacokinetic data: detectable serum levels are observed up to 8 hours after orally administered dose of amoxicillin. Following 1 gram dose and utilizing special skin window technique to determine levels of antibiotic, it was NOTE that therapeutic levels were found in interstitial fluid. Approximately 60% of orally administered doses of amoxicillin are excreted in urine within 6 to 8 hours. Amoxicillin is similar to ampicillin in its bactericidal action against susceptible organisms during the stage of active multiplication. It acts through inhibition of biosynthesis of cell wall mucopeptide. Amoxicillin has been shown to be active against most strains of following microorganisms, both in vitro and in CLINICAL infections as described in the INDICATIONS and USAGE section. Quantitative methods are used to determine antimicrobial minimum inhibitory concentrations. These MICs provide estimates of susceptibility of bacteria to antimicrobial compounds. Mics should be determined using a standardized procedure. Standardized procedures are based on dilution method 1 or equivalent with standardized inoculum concentrations and standardized concentrations of ampicillin powder. Ampicillin is sometimes used to predict susceptibility of S. Pneumoniae to amoxicillin; however, some intermediate strains have been shown to be susceptible to amoxicillin. Therefore, S. Pneumoniae susceptibility should be tested using amoxicillin powder.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

( Amoxicillin powder should be used to determine susceptibility.)

MIC (mcg/mL)Interpretation
2Susceptible (S)
4Intermediate (I)
8Resistant (R)

Enterobacteriaceae

MIC (mcg/mL)Interpretation
8Susceptible (S)
16Intermediate (I)
32Resistant (R)

H. influenzae c

MIC (mcg/mL)Interpretation
1Susceptible (S)
2Intermediate (I)
4Resistant (R)

Table

MicroorganismMIC Range (mcg/mL)
E. coli ATCC 259222 to 8
E. faecalis ATCC 292120.5 to 2
H. influenzae ATCC 49247d2 to 8
S. aureus ATCC 292130.25 to 1

Staphylococcusf

Zone Diameter (mm)Interpretation
29Susceptible (S)
28Resistant (R)

-hemolytic streptococci

Zone Diameter (mm)Interpretation
26Susceptible (S)
19 to 25Intermediate (I)
18Resistant (R)

H. influenzae g

Zone Diameter (mm)Interpretation
22Susceptible (S)
19 to 21Intermediate (I)
18Resistant (R)

Table2

MicroorganismZone diameter (mm)
E. coli ATCC 2592216 to 22
H. influenzae ATCC 49247 h13 to 21
S. aureus ATCC 2592327 to 35

Using 1 mcg oxacillin disk:

MicroorganismZone diameter (mm)
S. pneumoniae ATCC 49619 i8 to 12

Table3

MicroorganismMIC Range (mcg/mL)
E. coli ATCC 259222 to 8
E. faecalis ATCC 292120.5 to 2
H. influenzae ATCC 49247d2 to 8
S. aureus ATCC 292130.25 to 1

Table4

MicroorganismZone diameter (mm)
E. coli ATCC 2592216 to 22
H. influenzae ATCC 49247 h13 to 21
S. aureus ATCC 2592327 to 35
* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Microbiology:

Enterococcus

MIC (mcg/mL)Interpretation
8Susceptible (S)
16Resistant (R)

Amoxicillin is stable in the presence of gastric acid and is rapidly absorbed after ORAL administration. Amoxicillin diffuses readily into most body tissues and fluids, with the exception of brain and spinal fluid, except when meninges are inflame. The half - life of AMOXICILLIN is 61. 3 minutes. Most of AMOXICILLIN is excreted unchanged in urine; its excretion can be delayed by concurrent administration of probenecid. In the blood serum, AMOXICILLIN is approximately 20% protein - bound. Orally administered doses of 250 mg and 500 mg AMOXICILLIN Capsules result in average peak blood levels 1 to 2 hours after administration in a range of 3. 5 mcg / mL to 5 mcg / mL and 5. 5 mcg / mL to 7. 5 mcg / mL, respectively. Susceptibility Tests: Dilution Techniques: Quantitative Methods are used to determine Antimicrobial Minimum Inhibitory Concentrations. These MICs provide estimates of susceptibility of bacteria to antimi - crobial compounds. Mics should be determined USING standardized procedure. Standardized procedures are based on Dilution method 1 or equivalent with standardized inoculum Concentrations and standardized Concentrations of ampicillin powder. Ampicillin is sometimes used to predict Susceptibility of S. Pneumoniae to AMOXICILLIN; however, some intermediate strains have been shown to be Susceptible to AMOXICILLIN. Therefore, S. Pneumoniae Susceptibility should be Test USING AMOXICILLIN powder. Mic values should be interpreted according to the following criteria: report of Susceptible indicates that pathogen is likely to be inhibited if antimicrobial compound in blood reaches concentrations usually achievable. The Report of Intermediate indicates that the result should be considered equivocal, AND, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, test should be repeat. This category implies possible clinical applicability in body sites where drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer Zone, which prevents small uncontrolled technical factors from causing major discrepancies in interpretation. The Report of Resistant indicates that pathogen is not likely to be inhibited if antimicrobial compound in blood reaches concentrations usually achievable; other therapy should be select. Standardized Susceptibility Test procedures require use of Laboratory Control microorganisms to control technical aspects of laboratory procedures. Diffusion Techniques: Quantitative Methods that require measurement of Zone diameters also provide reproducible estimates of Susceptibility of Bacteria to Antimicrobial compounds. One such standardized procedure 2 requires use of standardized inoculum concentrations. This procedure uses paper disks impregnated with 10 mcg ampicillin to test the susceptibility of microorganisms, except S. Pneumoniae, to AMOXICILLIN. Interpretation involves correlation of diameter obtained in Disk Test with MIC For ampicillin. Reports from the Laboratory providing results of the Standard single - Disk Susceptibility Test with 10 mcg ampicillin Disk should be interpreted according to the following Criteria: S. Pneumoniae should be Test USING 1 mcg oxacillin Disk. Isolates with oxacillin Zone sizes of 20 mm are Susceptible to AMOXICILLIN. Amoxicillin MIC should be determined on isolates of S. Pneumoniae with oxacillin Zone sizes of 19 mm.


DESCRIPTION

Formulations of AMOXICILLIN contain AMOXICILLIN, semisynthetic antibiotic, analog of ampicillin, with a broad spectrum of bactericidal activity against many Grampositive and Gramnegative microorganisms. Chemically, it is - 63 3 - dimethyl - 7oxo - 4thia - 1azabicycloheptane - 2carboxylic acid trihydrate. It may be represented structurally as: AMOXICILLIN molecular formula is C 16 H 19 N 3 O 5 S3H 2 O, and molecular weight is 419. 45. Amoxicillin Capsules, USP: Each capsule of AMOXICILLIN, with a royal blue opaque cap and pink opaque body, contains 250 mg or 500 mg of AMOXICILLIN as trihydrate. The cap and body of the 250 - mg capsule are imprinted with product names AMOXIL and 250; cap and body of the 500mg capsule are imprinted with AMOXIL and 500. Inactive ingredients: D & C Red No. 28, FD & C Blue No. 1, FD & C Red No. 40, gelatin, magnesium stearate, and titanium dioxide. Amoxicillin Tablets, USP: Each tablet contains 500 mg or 875 mg of AMOXICILLIN as trihydrate. Each film - coat, capsule - shape, pink tablet is debossed with AMOXIL center over 500 or 875, respectively. 875 - mg tablet is score on the reverse side. Inactive ingredients: Colloidal silicon dioxide, crospovidone, FD & C Red No. 30 aluminum lake, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, sodium starch glycolate, and titanium dioxide. Amoxicillin Powder for Oral Suspension, USP: Each 5 mL of reconstituted Suspension contains 125 mg, 200 mg, 250 mg or 400 mg of AMOXICILLIN as trihydrate. Each 5 mL of 125 - mg reconstitute Suspension contains 0. 11 mEq of sodium. Each 5 mL of 200 - mg reconstitute Suspension contains 0. 15 mEq of sodium. Each 5 mL of 250mg reconstituted Suspension contains 0. 15 mEq of sodium; Each 5 mL of 400mg reconstituted Suspension contains 0. 19 mEq of sodium. Inactive ingredients: FD & C Red No. 3, flavorings, silica gel, sodium benzoate, sodium citrate, sucrose, and xanthan gum.


INDICATIONS AND USAGE

Triple therapy for Helicobacter pylori with clarithromycin and lansoprazole: Amoxicillin, in combination with clarithromycin plus lansoprazole as triple therapy, is indicated for treatment of patients with H. Pylori infection and duodenal ulcer disease to eradicate H. Pylori. Eradication of H. Pylori has been shown to reduce the risk of duodenal ulcer recurrence. Dual therapy for H. Pylori with lansoprazole: Amoxicillin, in combination with lansoprazole delayedrelease capsules as dual therapy, is indicated for treatment of patients with H. Pylori infection and duodenal ulcer disease who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is know or suspect. Eradication of H. Pylori has been shown to reduce the risk of duodenal ulcer recurrence.


WARNINGS

Clostridium difficile associated diarrhea has been reported with the use of nearly all antibacterial agents, including amoxicillin, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters normal flora of colon, leading to overgrowth of C. Difficile. C. Difficile produces toxins and B, which contributed to the development of CDAD. Hypertoxin - producing strains of C. Difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. Cdad must be considered in all patients who present with diarrhea following antibacterial use. Careful medical history is necessary since CDAD has been reported to occur over 2 months after administration of antibacterial agents. If CDAD is suspected or confirm, ongoing antibiotic use not direct against C. Difficile may need to be discontinue. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. Difficile, and surgical evaluation should be instituted as clinically indicate.


ADVERSE REACTIONS

In addition to adverse events reported from clinical trials, following events have been identified during postmarketing use of penicillins. Because they are reported voluntarily from population of unknown size, estimates of frequency cannot be make. These events have been chosen for inclusion due to combination of their seriousness, frequency of reporting, or potential causal connection to AMOXICILLIN. Infections and Infestations: Mucocutaneous candidiasis. Gastrointestinal: Black hairy tongue, and hemorrhagic / pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment. Hypersensitivity Reactions: Anaphylaxis. Serum sickness - like reactions, erythematous maculopapular rashes, erythema multiforme, StevensJohnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis, acute generalize exanthematous pustulosis, hypersensitivity vasculitis, and urticaria have been report. Liver: moderate rise in AST and / or ALT has been note, but the significance of this finding is unknown. Hepatic dysfunction including cholestatic jaundice, hepatic cholestasis and acute cytolytic hepatitis have been report. Renal: Crystalluria has been report. Hemic and Lymphatic Systems: Anemia, including hemolytic Anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have been report. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena. Central Nervous System: Reversible hyperactivity, agitation, anxiety, insomnia, confusion, convulsions, behavioral changes, and / or dizziness have been reported. Miscellaneous: Tooth discoloration has been report. Most reports occur in pediatric patients. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases.


What is AMOXIL used for?

Swallow AMOXIL 250mg and 500mg capsules whole with a glass of water. To prepare AMOXIL 3g syrup sachet, powder from the sachet is emptied into a glass. The empty sachet is then half filled with water and this is added to powder in glass. Stir medicine thoroughly before drinking. Dose should be taken immediately after preparation. Space dose as evenly as possible throughout the day. For example, if you are taking AMOXIL three times a day, take dose about every eight hours. Amoxil can be taken with or without food. The effects of AMOXIL are not changed by food.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

Staphylococcus a

MIC (mcg/mL)Interpretation
0.25Susceptible (S)
0.5Resistant (R)

Streptococcus (except S. pneumoniae )

MIC (mcg/mL)Interpretation
0.25Susceptible (S)
0.5 to 4Intermediate (I)
8Resistant (R)

( Amoxicillin powder should be used to determine susceptibility.)

MIC (mcg/mL)Interpretation
2Susceptible (S)
4Intermediate (I)
8Resistant (R)

Enterobacteriaceae

MIC (mcg/mL)Interpretation
8Susceptible (S)
16Intermediate (I)
32Resistant (R)

H. influenzae c

MIC (mcg/mL)Interpretation
1Susceptible (S)
2Intermediate (I)
4Resistant (R)

Using amoxicillin to determine susceptibility:

MicroorganismMIC Range (mcg/mL)
E. coli ATCC 259222 to 8
E. faecalis ATCC 292120.5 to 2
H. influenzae ATCC 49247 d2 to 8
S. aureus ATCC 292130.25 to 1
S pneumoniae ATCC 49619 e0.03 to 0.12

Staphylococcus f

Zone Diameter (mm)Interpretation
29Susceptible (S)
28Resistant (R)

- hemolytic streptococci

Zone Diameter (mm)Interpretation
26Susceptible (S)
19 to 25Intermediate (I)
18Resistant (R)

H. influenzae g

Zone Diameter (mm)Interpretation
22Susceptible (S)
19 to 21Intermediate (I)
18Resistant (R)

Table

MicroorganismZone Diameter (mm)
E. coli ATCC 2592216 to 22
H. influenzae ATCC 49247 h13 to 21
S. aureus ATCC 2592327 to 35

Using 1-mcg oxacillin disk:

MicroorganismZone Diameter (mm)
S. pneumoniae ATCC 49619 i8 to 12

Streptococcus (except S. pneumoniae)

MIC (mca /mL)Interpretation
0.25Susceptible (S)
0.5 to 4Intermediate (I)
8Resistant (R)

S. pneumoniae b from non-meningitis sources. (Amoxicillin powder should be used to determine susceptibility.)

MIC (mca /mL)Interpretation
2Susceptible (S)
4Intermediate (I)
8Resistant (R)

-hemolytic streptococci

Zone Diameter (mm)Interpretation
26Susceptible (S)
19 to 25Intermediate (I)
18Resistant (R)

Enterobacteriacea e

Zone Diameter (mm)Interpretation
17Susceptible (S)
14 to 16Intermediate (I)
13Resistant (R)

H. pylori Eradication Rates - Triple Therapy (amoxicillin/ clarithromycin /lansoprazole) Percent of Patients Cured (Number of Patients)

StudyTriple TherapyTriple Therapy
Evaluable AnalysisIntent-to-Treat Analysis
Study 19286
(n = 48)(n = 55)
Study 28683
(n = 66)(n = 70)

H. pylori Eradication Rates - Dual Therapy (amoxicillin/lansoprazole) Percent of Patients Cured (Number of Patients)

StudyDual TherapyDual Therapy
Evaluable AnalysisIntent-to-Treat
Analysis
Study 17770
(n = 51)(n = 60)
Study 26661
(n = 58)(n = 67)
* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

INDICATIONS AND USAGE

Amoxicillin is indicated in treatment of infections due to susceptible strains of designated microorganisms in conditions list below: infections of ear, nose, and throat - due to Streptococcus spp., S. Pneumoniae, Staphylococcus spp., Or H. Influenzae. Infections of genitourinary tract - due to E. Coli, P. Mirabilis, or E. Faecalis. Infections of skin and skin structure - due to Streptococcus spp., Staphylococcus spp., Or E. Coli. Infections of the lower respiratory tract - due to Streptococcus spp., S. Pneumoniae, Staphylococcus spp., Or H. Influenzae. Gonorrhea, acute uncomplicated - due to N. Gonorrhoeae. H. Pylori eradication to reduce risk of duodenal ulcer recurrence. Amoxicillin, in combination with clarithromycin plus lansoprazole as triple therapy, is indicated for treatment of patients with H. Pylori infection and duodenal ulcer disease to eradicate H. Pylori. Eradication of H. Pylori has been shown to reduce the risk of duodenal ulcer recurrence. Amoxicillin, in combination with lansoprazole delay - release capsules as dual therapy, is indicated for treatment of patients with H. Pylori infection and duodenal ulcer disease who are either allergic or intolerant to clarithromycin or in whom resistance to clarithromycin is known or suspect. Eradication of H. Pylori has been shown to reduce the risk of duodenal ulcer recurrence. To reduce development of drug - resistant bacteria and maintain the effectiveness of amoxicillin and other antibacterial drugs, amoxicillin should be used ONLY to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information is available, it should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to empiric selection of therapy.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

WARNINGS

For people with mononucleosis: Amoxicillin raises your risk of developing severe rash. For people with diabetes: Amoxicillin may cause you to have a false - positive reaction when testing for glucose in urine. Talk with your doctor about how to manage your blood sugar while taking Amoxicillin. For people with kidney disease: If you have severe kidney disease, your kidneys may not clear this drug from your body quickly. As a result, levels of Amoxicillin may build up in your body. To help prevent this, your doctor may give you a lower dose of this drug.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

PRECAUTIONS

Amoxicillin is used to treat certain infections caused by bacteria, such as pneumonia; bronchitis; and infections of the ears, nose, throat, urinary tract, and skin. It is also used in combination with other medications to eliminate H. Pylori, bacteria that causes ulcers. Amoxicillin is in a class of medications called penicillin - like antibiotics. It works by stopping the growth of bacteria. Antibiotics such as amoxicillin will not work for colds, flu, and other viral infections. Taking antibiotics when they are not needed increases your risk of getting infection later that resist antibiotic treatment. Amoxicillin comes as a capsule, tablet, chewable tablet, and as a suspension to take by mouth. It is usually Take every 12 hours or every 8 hours with or without food. The length of your treatment depends on the type of infection that you have. Take amoxicillin at around the same time every day. Follow directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take amoxicillin exactly as directly Do not take more or less of it or take it more often than prescribed by your doctor. Shake suspension well before each use to mix medication evenly. Suspension may be placed directly on the child's tongue or added to formula, milk, fruit juice, water, ginger ale, or another cold liquid and taken immediately. Chewable tablets should be crushed or chewed thoroughly before they are swallow. Swallow tablets and capsules whole with a full glass of water; do not chew or crush them. You should begin to feel better during the first few days of treatment with amoxicillin. If your symptoms do not improve or get worse, call your doctor. Take amoxicillin until you finish the prescription, even if you feel better. If you stop taking amoxicillin too soon or skip doses, your infection may not be completely treated and bacteria may become resistant to antibiotics.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Labor and Delivery:

Serious, and occasionally fatal, hypersensitivity reactions have been reported in patients receiving beta - lactam antibiotics. Although anaphylaxis is more frequent following parenteral therapy, it has occurred in patients on oral therapy. Before commencing therapy with any penicillin, careful enquiry should be made concerning previous hypersensitivity reactions to penicillins, cephalosporins or other allergens. If allergic reaction occur, appropriate therapy should be instituted and Amoxicillin therapy discontinue. Serious anaphylactic reactions require immediate emergency treatment with adrenaline. Oxygen, intravenous steroids and airway management, including intubation, should also be administered as indicated. Antibiotics associated with pseudomembranous colitis have been reported with many antibiotics, including Amoxicillin. Toxin produced with Clostridium difficile appears to be the primary cause. Severity of colitis may range from mild to life threatening. Clostridium difficile associated diarrhoea has been reported with the use of nearly all antibacterial agents and may range in severity from mild diarrhoea to fatal colitis. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use. If prolonged or significant diarrhoea occurs or the patient experiences abdominal cramps, treatment should be discontinued immediately and the patient investigated further. Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with suitable oral antibiotic agent effective against Clostridium difficile should be consider. Fluids, electrolytes and protein replacement should be provided when indicate. Drugs which delay peristalsis, eg opiates and diphenoxylate with atropine may prolong and / or worsen condition and should not be used. Adequate fluid intake and urinary output must be maintained in patients receiving high doses of Amoxicillin. Abnormal prolongation of prothrombin time has been reported rarely in patients receiving Amoxicillin and oral anticoagulants. Appropriate monitoring should be undertaken when anticoagulants are prescribed concurrently. Adjustments in the dose of oral anticoagulants may be necessary to maintain the desired level of anticoagulation. Amoxicillin should be avoided if infectious mononucleosis is suspect since occurrence of morbilliform rash has been associated with this condition following use of Amoxicillin. Prolong use occasionally results in overgrowth of non - susceptible organisms. As with any potent drug, periodic assessment of renal, hepatic and haematopoietic function should be made during prolonged therapy. The possibility of superinfections with mycotic or bacterial pathogens should be kept in mind during therapy. If superinfections occur, drug should be discontinued and / or appropriate therapy institute. Amoxicillin, aminopenicillin, is not the treatment of choice in patients presenting with sore throat or pharyngitis because of the possibility that the underlying cause is infectious mononucleosis, in presence of which there is a high incidence of rash if Amoxicillin is used. Amoxicillin should be given with caution to patients with lymphatic leukaemia since they are especially susceptible to ampicillin - induced skin rashes. Following single dose therapy for acute lower urinary tract infections, urine should be culture. Positive culture may be evidence of complicated or upper urinary tract infection and calls for longer or larger courses of therapy.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Geriatric Use:

Analysis of clinical studies of amoxicillin was conducted to determine whether subjects aged 65 and over responded differently from younger subjects. Of 1 811 subjects treated with capsules of amoxicillin, 85% were < 60 years old, 15% were 61 years old and 7% were 71 years old. This analysis and other reports clinical experience have not identified differences in responses between elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. This drug is known to be substantially excreted by kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Amoxicillin may interact with other medications

When amoxicillin is less effective: When amoxicillin is used with certain drugs, it may not work as well. This is because the amount of amoxicillin in your body may decrease. Examples of these drugs include: chloramphenicol. If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same. Macrolides, such as erythromycin, clarithromycin, or azithromycin If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same. Sulfonamides, such as sulfamethoxazole If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same. Tetracyclines, such as tetracycline or doxycycline If you use these drugs together, your doctor will likely keep your dosage of amoxicillin the same. When other drugs are less effective: When certain drugs are used with amoxicillin, they may not work as well. This is because the amount of these drugs in your body may decrease. Examples of these drugs include: oral contraceptives. If you need to take amoxicillin, your doctor may prescribe a different form of birth control for you.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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