Ankyrin-B Syndrome

Summarized by Plex Health
Last Updated: 02 May 2022
ankyrin-b syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. "ankyrin-b syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence.", by Mohler PJ, Healy JA, Xue H, Puca AA, Kline CF, Allingham RR, Kranias EG, Rockman HA, Bennett V. pone-0001051-g004: Ankyrin-B+/− mice display premature senescence and reduced longevity.Gross phenotypes of wild-type and ankyrin-B+/− mice at (A) eight weeks, (B) six months, and C) two years. While we observe no major differences in phenotypes at...

Ankyrin-B syndrome is connected with a range of heart issues related to interruption of the heart's normal rhythm. Heart rhythm is regulated by electrical signals that move with the heart in a highly worked with way. In a small number of people with ankyrin-B syndrome, the heart takes longer than typical to reenergize between beats, which is referred to as a prolonged QT interval. Other heart problems that occur in ankyrin-B syndrome consist of uncoordinated and uneven electric activity in the heart's top chambers or lower chambers and an irregularity called catecholaminergic polymorphic ventricular tachycardia, in which an increase in the heart rate can set off a extraordinarily quick and uneven heart beat called ventricular tachycardia. When related to an extended QT interval, the problem is sometimes categorized as long QT syndrome 4. Nevertheless, since extra heart troubles can result from changes in the same genetics, lengthy QT syndrome 4 is usually considered part of ankyrin-B syndrome.

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