Anonychia Congenita

Summarized by Plex Health
Last Updated: 02 May 2022

Anonychia congenita is a condition that influences the toe nails and finger nails. Sometimes, only part of the nail is missing out on or not all fingers and toes are affected. Individuals with anonychia congenita do not have any other wellness troubles associated to the problem. Anonychia congenita is uncommon condition; its occurrence is unidentified. Wnt signaling is essential for cell department, accessory of cells to each other, cell movement, and many other cellular activities. During very early growth, Wnt signaling plays a vital role in the growth and advancement of nails. RSPO4 gene mutations lead to the production of a protein with little or no function. Anonychia congenita can become part of syndromes that impact numerous components of the body, consisting of Coffin-Siris syndrome and nail-patella syndrome. When anonychia congenita belongs to a syndrome, it is triggered by mutations in the gene associated with that disorder.

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