It causes arteries to become clogged with fatty substances called plaques, or atheroma. Histologically, arteriosclerosis is characterized by degeneration and splitting of the internal elastic lamina in the tunica media with buildup of mucopolysaccharide substance. While arteriosclerosis is not considered inflammatory, swelling might be a predisposing aspect. Lesions with substantial narrowing of the lumen may add to distal ischemia and subsequent thrombus formation, as arterial branching points are favored sites of sore advancement. The extent and extent of the lesions correlate positively with breeding regularity, and lesions are normally more serious in women than in men. Atherosclerosis is a type of arteriosclerosis which contains a lipid element. These plaques cause the arteries to solidify and narrow, limiting the blood circulation and oxygen supply to vital organs, and increasing the risk of blood embolisms that could possibly obstruct the flow of blood to the heart or brain. Vascular enlarging and luminal constricting that occur with arteriosclerosis can ultimately lead to ischemic change. Atherosclerosis typically leads to more constricting of the vascular lumen due to plaque development having lipid and macrophages.
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