Auranofin

Summarized by Plex Health
Last Updated: 02 May 2022
repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. "repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis.", by Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, Chen S, Wilson C, Ang KH, Arkin M, Gut J, Franklin C, Marcellino C, McKerrow JH, Debnath A, Sakanari JA. pntd.0003534.g001: TEM images of auranofin treated B. pahangi.Transmission electron microscopy of auranofin treated versus control adult female Brugia pahangi after overnight drug treatment. (A) B. pahangi treated with 1 μM of auranofin. Hypodermal chord region...

Auranofin is a form of gold that reduces some of the impacts of the inflammatory procedure in the body. Auranofin is used to treat rheumatoid arthritis in adults. Auranofin is usually provided only to people unable to use other RA medicines, or when other treatments did not work or have quit working. Auranofin might also be used for other objectives not provided in this medication overview. You should not use auranofin if you have ever had a severe reaction to gold therapy that affected your skin, lungs, bone marrow, blood cells, or your stomach or intestinal tracts. It is not recognized whether auranofin will harm a coming baby. Your physician may occasionally change your dose. If your symptoms do not boost after 3 or 4 months of treatment, keep using the drug as guided and inform your doctor. Auranofin can increase your risk of bleeding or infection. Take the medicine as quickly as you can, however skip the missed out on dosage if it is practically time for your next dose.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
24199313C20H34AuO9PS678.5CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]CCP(CC)CC.CC(=O)OCC1C(C(C(C(O1)[S-])OC(=O)C)OC(=O)C)OC(=O)C.[Au+]InChI=1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1AUJRCFUBUPVWSZ-UHFFFAOYSA-Mgold(1+);3,4,5-triacetyloxy-6-(acetyloxymethyl)oxane-2-thiolate;triethylphosphane678.132686678.1326861155320010123205050003
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