Azathioprine

Summarized by Plex Health
Last Updated: 02 May 2022
ptch mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients. "ptch mutations in basal cell carcinomas from azathioprine-treated organ transplant recipients.", by Harwood CA, Attard NR, O'Donovan P, Chambers P, Perrett CM, Proby CM, McGregor JM, Karran P. fig1: PTCH mutation spectra in BCC from azathioprine- and non-azathioprine-treated patients. A similar proportion of UVB and oxidation-type mutations is present in each group. The G:C to A:T transition mutations at non-dipyrimidine sites (hatched) occured...

Azathioprine is a medication available in the form of a tablet computer that is used to deal with immune diseases, especially several sclerosis. Research has found that this medication can lower the circumstances of flare-ups in people with relapsing several sclerosis. Currently, the FDA has not authorized azathioprine for multiple sclerosis. Azathioprine is used to avoid being rejected in a transplant. Azathioprine comes from the drug course called immunosuppressants. Your doctor will examine your weight and white blood cell count to prescribe the excellent dose of this medication. In some cases, your medical professional might suggest you to take the tablet computer with food to lower the risk of abdominal symptoms and nausea. Although azathioprine can aid manage the symptoms of rheumatoid arthritis, it does not cure the disease. When the immune system deals with the new body organ as an intruder and attacks it, body organ rejection occurs. Azathioprine may cause uncommon type of lymphoma of the bone, spleen, and liver marrow that can be fatal. Each racked up tablet computer has 50 mg, 75 mg or 100 mg azathioprine, USP and the inactive ingredients anhydrous lactose, magnesium stearate, povidone, pregelatinized starch, and stearic acid. Azathioprine is chemically 1H-Purine, 6- [thio] -. The structural formula of azathioprine is: It is an imidazolyl by-product of Many and 6-mercaptopurine of its organic results are comparable to those of the parent substance. Azathioprine, USP is steady in option at neutral or acid pH but hydrolysis to mercaptopurine happens over sodium hydroxide, especially on warming. Conversion to mercaptopurine also takes place in the existence of sulfhydryl substances such as glutathione, cysteine and hydrogen sulfide.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
2265C9H7N7O2S277.27CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]CN1C=NC(=C1SC2=NC=NC3=C2NC=N3)[N+](=O)[O-]InChI=1S/C9H7N7O2S/c1-15-4-14-7(16(17)18)9(15)19-8-5-6(11-2-10-5)12-3-13-8/h2-4H,1H3,(H,10,11,12,13)LMEKQMALGUDUQG-UHFFFAOYSA-N6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine0.1277.03819367277.0381936714335401721900000001
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