BCR ABL Genetic Test

Summarized by Plex Health
Last Updated: 02 May 2022

A BCR-ABL genetic test searches for a genetic mutation on a specific chromosome. Chromosomes are the components of your cells which contain your genes. Genes become part of DNA given from your mother and father. When pieces of BCR and ABL genes damage off and switch areas, the BCR-ABL mutation takes place. The piece of chromosome 9 that breaks short consists of part of the ABL gene. When this item conforms to chromosome 22, part of the ABL gene affixes to the BCR gene. The joined genetics is called the BCR-ABL blend genetics. The changed chromosome 22, which contains the BCR-ABL gene, is called the Philadelphia chromosome because that's the city where researchers first uncovered it. The BCR-ABL genetics is not the type of mutation that is acquired from your parents. BCR-ABL is found in nearly all patients with a type of leukemia called chronic myeloid leukemia. The BCR-ABL gene is additionally found in some patients with a type of intense lymphoblastic leukemia and rarely in patients with severe myelogenous leukemia. Specific cancer medications are specifically efficient in dealing with leukemia patients with the BCR-ABL genetics mutation. These medications also have fewer side effects than other cancer treatments. Other names: BCR-ABL1, BCR-ABL1 blend, Philadelphia chromosome A BCR-ABL test is frequently used to rule or diagnose out persistent myeloid leukemia or a specific type of intense lymphoblastic leukemia called Ph-positive ALL. The test may be used to: See if cancer therapy works.

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