Bempedoic Acid
Summarized by Plex Health
Last Updated: 02 May 2022
"liver-specific atp-citrate lyase inhibition by bempedoic acid decreases ldl-c and attenuates atherosclerosis", by . f6: The mechanism of action of ETC-1002.In liver, ETC-1002 (bempedoic acid) is activated to ETC-1002-CoA by ACSVL1, and subsequently inhibits ACL. Similar to inhibition of HMG-CoA reductase (HMGR) by statins, inhibition of liver ACL by...
Bempedoic acid is used together with diet plan and other medications to lower blood degrees of "bad" cholesterol. Bempedoic acid is for use in adults with an acquired form of high cholesterol. Bempedoic acid is also used to lower LDL cholesterol in adults with coronary artery disease. It is not recognized if bempedoic acid can lower the risk of complications associated to high cholesterol. Bempedoic acid may additionally be used for purposes not listed in this drug overview. Bempedoic acid may cause tearing or swelling of a tendon, particularly in the arm, shoulder, or Achilles' ligament of the heel. Ligament problems might be more likely in certain people older adults, people with kidney disease, or people who take steroid medication or particular prescription antibiotics. Bempedoic acid may damage a coming infant. You might take bempedoic acid with or without food. Take the medication as quickly as you can, yet skip the missed dosage if it is almost time for your following dosage.
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Research Papers' Summaries
PubChem - CovalentUnitCount
(Table source)| CID | MolecularFormula | MolecularWeight | CanonicalSMILES | IsomericSMILES | InChI | InChIKey | IUPACName | XLogP | ExactMass | MonoisotopicMass | TPSA | Complexity | Charge | HBondDonorCount | HBondAcceptorCount | RotatableBondCount | HeavyAtomCount | IsotopeAtomCount | AtomStereoCount | DefinedAtomStereoCount | UndefinedAtomStereoCount | BondStereoCount | DefinedBondStereoCount | UndefinedBondStereoCount | CovalentUnitCount |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10472693 | C19H36O5 | 344.5 | CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O | CC(C)(CCCCCC(CCCCCC(C)(C)C(=O)O)O)C(=O)O | InChI=1S/C19H36O5/c1-18(2,16(21)22)13-9-5-7-11-15(20)12-8-6-10-14-19(3,4)17(23)24/h15,20H,5-14H2,1-4H3,(H,21,22)(H,23,24) | HYHMLYSLQUKXKP-UHFFFAOYSA-N | 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid | 4.8 | 344.25627424 | 344.25627424 | 94.8 | 351 | 0 | 3 | 5 | 14 | 24 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
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