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Beta Thalassemia

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Last Updated: 21 October 2021

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General | Latest Info

Beta Thalassemia

CausesMutations in the HBB gene
Diagnostic methodDNA analysis
Other namesMicrocytemia, beta type
SpecialtyHematology
TreatmentDepends on type (see types)
TypesThalassemia minor, intermediate and major

Thalassemia is a blood problem that is acquired. Hemoglobin is the iron-containing healthy protein in red cell that lugs oxygen to cells throughout the body. People with beta thalassemia go to a raised danger of establishing irregular embolism.

Beta thalassemia is classified into 2 types depending on the severity of signs: thalassemia major and thalassemia intermedia. Many people with thalassemia major have such severe symptoms that they need frequent blood transfusions to restore their red blood cell supply. The reduced number of fully grown red blood cells results in anemia and various other affiliated health issue in people with beta thalassemia.

Thalassemia intermedia: this type can create signs of moderate to severe anemia consisting of: Extreme fatigue; Pale skin; Slow or postponed growth; Weak bones; Enlarged spleen Beta thalassemia is frequently found in people that are of Greek, Italian, African, or Asian origin. These examinations might have the ability to tell if you are a provider, and can pass the disorder on your youngsters: Complete blood count: This examination checks the dimension, number, and maturation of different blood cells in an established volume of blood. ; Different people will have various symptoms, based on which kind of beta thalassemia is inherited. ; Treatment of beta thalassemia might include medications and regular blood transfusions. People with beta thalassemia minor usually do not have any signs and people usually are uninformed that they have the problem. Iron overload can harm the heart, triggering uncommon heart rhythms, swelling of the membrane that lines the heart, enhancement of the heart and condition of the heart muscle. The decrease or lack of beta globin protein chains results in a discrepancy with the normally-produced alpha globin protein chains and, inevitably, the malfunctioning formation of red cell, an absence of useful hemoglobin, and the failing to supply enough amounts of oxygen to the body.

Beta thalassemia may additionally take place in addition to another problem in which there is a problem in the framework of hemoglobin.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

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20 November 2019Beta Thalassemia - causes, symptoms, diagnosis, treatment, pathology

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Beta Thalassemia (latest news)

Iron overload has an unfavorable connection with some measures of endocrine function in patients with transfusion-dependent beta thalassemia and growth retardation, according to research in the Journal of Blood Medicine. Previous studies have revealed that patients with thalassemia often tend to have endocrine problems. The study writers sought to determine a relationship in between transfusion-dependent beta thalassemia and growth retardation in grown-up patients in Indonesia.

Atmakusuma TD, Hasibuan FD, Purnamasari D. The relationship in between iron overload and endocrine function in grown-up transfusion-dependent beta-thalassemia patients with development retardation.

A rolling submission of a biologic license application to the FDA has been finished for betibeglogene autotemcel for use in adult, teen, and pediatric patients with beta-thalassemia who require normal red blood cell transfusions, across all genotypes. With this submission, we are one step more detailed to bringing a potentially transformative gene therapy to people dealing with transfusion-dependent beta-thalassemia and their families, Andrew Obenshain, president of severe genetic conditions at bluebird biography, specified in a press release.

Results suggested that 91% of the 22 pediatric patients who were aged 4 to 17 years attained transfusion independence adhering to treatment with beti-cel; this included 10 patients who were under 12 years of age. The median heavy ordinary hemoglobin level during transfusion freedom was 10. 0 g/dL in 10 patients under age 12, and 11. 7 g/dL in 10 patients in between the ages of 12 and 18 years.

Bluebird biography announced it completed the rolling entry of its BLA to the FDA for betibeglogene autotemcel gene therapy. If authorized, beti-cel will be the first hematopoietic stem cell ex-vivo genetics therapy for patients in the United States.

We look onward to collaborating with the FDA on its review of this BLA as we realize the assurance that one-time gene treatments hold for patients, stated new bluebird president Andrew Obenshain in a statement.

Bluebird remained in the news recently as the previous CEO, Nick Leschly, branched off to lead a new business in 2seventy, dividing the gene therapy and rare illness and gene therapy pipe from its efforts in oncology.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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