Bicalutamide

Summarized by Plex Health
Last Updated: 03 May 2022

Bicalutamide is a prescription medicine belonging to a course of medications called non-steroidal androgen receptor inhibitors. The chemical name is propanamide, N [4 cyano-3phenyl] -3 [sulfonyl] -2 hydroxy-2methyl-,. The empirical and structural solutions are: Bicalutamide has a molecular weight of 430. 37. The pKa is about 12. Bicalutamide is a fine white to off-white powder which is virtually insoluble in water at 37 C, somewhat soluble in chloroform and absolute ethanol, moderately soluble in methanol, and soluble in acetone and tetrahydrofuran. Bicalutamide is a racemate with its antiandrogenic task being almost solely displayed by the R-enantiomer of bicalutamide; the S-enantiomer is essentially non-active. The non-active components of bicalutamide tablets, USP are lactose monohydrate, magnesium stearate, hypromellose E5, polyethylene glycol 400, povidone K 30, salt starch glycolate, and titanium dioxide. Bicalutamide tablets, USP 50 mg satisfies USP Dissolution Test 2.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
2375C18H14F4N2O4S430.4CC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)OCC(CS(=O)(=O)C1=CC=C(C=C1)F)(C(=O)NC2=CC(=C(C=C2)C#N)C(F)(F)F)OInChI=1S/C18H14F4N2O4S/c1-17(26,10-29(27,28)14-6-3-12(19)4-7-14)16(25)24-13-5-2-11(9-23)15(8-13)18(20,21)22/h2-8,26H,10H2,1H3,(H,24,25)LKJPYSCBVHEWIU-UHFFFAOYSA-NN-[4-cyano-3-(trifluoromethyl)phenyl]-3-(4-fluorophenyl)sulfonyl-2-hydroxy-2-methylpropanamide2.3430.06104075430.0610407511675002952901010001
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