Bicalutamide

Bicalutamide is a prescription medicine belonging to a course of medications called non-steroidal androgen receptor inhibitors. The chemical name is propanamide, N [4 cyano-3phenyl] -3 [sulfonyl] -2 hydroxy-2methyl-,. The empirical and structural solutions are: Bicalutamide has a molecular weight of 430. 37. The pKa is about 12. Bicalutamide is a fine white to off-white powder which is virtually insoluble in water at 37 C, somewhat soluble in chloroform and absolute ethanol, moderately soluble in methanol, and soluble in acetone and tetrahydrofuran. Bicalutamide is a racemate with its antiandrogenic task being almost solely displayed by the R-enantiomer of bicalutamide; the S-enantiomer is essentially non-active. The non-active components of bicalutamide tablets, USP are lactose monohydrate, magnesium stearate, hypromellose E5, polyethylene glycol 400, povidone K 30, salt starch glycolate, and titanium dioxide. Bicalutamide tablets, USP 50 mg satisfies USP Dissolution Test 2.

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