Indigenous to eastern Africa, the Arabian Peninsula, Syria, and Southeast Asia, bitter orange now is grown throughout the Mediterranean region and somewhere else, including California and Florida. Bitter orange has been used in typical Chinese medication for nausea or vomiting, constipation, and acid indigestion. Bitter orange is also related to the skin for pain, swellings, fungal infections, and bedsores. Bitter orange is used in cooking and for adding taste to beer and spirits. The fruit of bitter orange consists of p-synephrine and other naturally happening chemicals. p-Synephrine is structurally comparable to ephedrine, the main element in the natural herb ephedra, but p-synephrine has different pharmacologic properties. Because it raises blood pressure and is connected to heart attack and stroke, the U. S. Food and Drug Administration outlawed the use of ephedra in nutritional supplements. Bitter orange is typically used as an alternative for ephedra in dietary supplements. A handful of studies have explored the usefulness of bitter orange for health objectives in people. Using bitter orange oil to the skin might aid with ringworm, jock impulse, and athlete's foot infections.
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