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Bosutinib

Summarized by Plex Health
Last Updated: 02 May 2022
the clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases. "the clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases.", by Ozanne J, Prescott AR, Clark K. F5: Bosutinib and dasatinib induce the dephosphorylation of CRTC3 and its nuclear translocation(A) RAW264.7 macrophages were treated with bosutinib, dasatinib, HG-9-91-01 or vehicle control for 1 h. CRTC3 was immunoprecipitated and phosphorylation of Ser162 and...

Bosutinib is used in adults to treat a type of blood cancer called Philadelphia chromosome-positive chronic myelogenous leukemia. Leukemia is a type of cancer where the body makes abnormal leukocyte. Bosutinib is an antineoplastic medication. It hinders the development of cancer cells, which are eventually damaged by the body. Since the development of normal cells might additionally be affected by bosutinib, opposite side effects can occur. Prior to you start treatment, talk to your physician about the benefits of this medication as well as the possible dangers of utilizing it. This medicine is readily available only with your medical professional's prescription.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
5328940C26H29Cl2N5O3530.4CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OCCN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OCInChI=1S/C26H29Cl2N5O3/c1-32-6-8-33(9-7-32)5-4-10-36-25-13-21-18(11-24(25)35-3)26(17(15-29)16-30-21)31-22-14-23(34-2)20(28)12-19(22)27/h11-14,16H,4-10H2,1-3H3,(H,30,31)UBPYILGKFZZVDX-UHFFFAOYSA-N4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile5.4529.1647452529.164745282.973401893600000001
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