Busulfan is a bifunctional alkylating agent known chemically as 1,4- butanediol, dimethanesulfonate. Each vial of BUSULFEX contains 60 mg of busulfan, the active component, a white crystalline powder with a molecular formula of CH3SO2O4OSO2CH3 and a molecular weight of 246 g/mole. The solubility of busulfan in water is 0. 1 g/L and the pH of BUSULFEX diluted to approximately 0. 5 mg/mL busulfan in 0. 9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP as recommended for infusion reflects the pH of the diluent used and ranges from 3. 4 to 3. 9.
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