Summarized by Plex Health
Last Updated: 10 May 2022
vta crf neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. "vta crf neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation.", by Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, Tapper AR, Roberto M, Kieffer BL, Sawchenko PE, Koob GF, van der Kooy D, George O. F3: Double labeling of CRF/DA neurons using CRF in situ hybridization and TH immunohistochemistry in micea, CRF mRNA radioactive in situ hybridization (black) demonstrating CRF-positive cell bodies (arrows) in the pVTA. b, TH immunohistochemistry (red)...

The DAIDS RSC Case Report Form Management Team works closely with DAIDS and Clinical Research Sites to promote this procedure. This web page is developed to walk users via the process of figuring out whether a Clinical Research Site's CRF records can be moved to DAIDS for long-lasting storage space, and if so how to complete that procedure. Only CRFs and drug store records might be shipped to DAIDS by means of the DAIDS RSC for long-term storage space. The DAIDS RSC CRF Management Team works closely with DAIDS to keep updated checklists of IND and non-IND DAIDS-sponsored or -funded protocols that are no longer needed to have their CRFs or Pharmacy Records retained to be in conformity with regulative guidelines and DAIDS plans. These are the procedures for which DAIDS WILL NOT concur to have papers sent for lasting storage since DAIDS has identified that the records connected with these studies no longer call for storage space and that they may be destroyed in accordance with the investigator's institutional plans. If your protocol IS NOT consisted of on the listings listed below, after that you can continue with the process for Sending CRFs to DAIDS for Storage as detailed in the Process for Sending CRFs to DAIDS for Storage area listed below. The Clinical Research Site requires to verify with their establishment whether they can ruin the records from the protocols provided in the documents over. The Instructions document lays out the processes for obtaining DAIDS approval and the transfer of the CRFs and pharmacy records. The Principal Investigator is in charge of submitting the demand for consent to deliver CRFs and pharmacy records to DAIDS by means of the DAIDS RSC.

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