Candesartan

Summarized by Plex Health
Last Updated: 02 May 2022
an integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for alzheimer's disease. "an integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for alzheimer's disease.", by Elkahloun AG, Hafko R, Saavedra JM. Fig6: Cellular origin of gene expression in Alzheimer’s disease hippocampus. There are 580 genes upregulated (red) and 1430 downregulated (blue) differentially expressed transcripts in hippocampus from Alzheimer’s disease patients which are common to both GSE48350...

Candesartan is used alone or along with other medicines to treat high blood pressure in children and adults 1 to 16 years old. Candesartan is a selective AT1 subtype angiotensin II receptor antagonist. Candesartan cilexetil, USP a nonpeptide, is chemically called -1 Hydroxyethyl 2-ethoxy-1 [p-benzyl] -7 benzimidazolecarboxylate, cyclohexyl carbonate. Its molecular formula is C33H34N6O6, and its structural formula is: Candesartan cilexetil, USP is a white to beige powder with a molecular weight of 610. 67. It is virtually insoluble in water and sparingly soluble in methanol. Candesartan cilexetil USP is a racemic mix having one chiral center at the cyclohexyloxycarbonyloxy ethyl ester group. Following oral administration, candesartan cilexetil undertakes hydrolysis at the ester link to form the active medicine, candesartan, which is achiral. Candesartan cilexetil, USP is readily available for oral use as tablets consisting of either 4 mg, 8 mg, 16 mg, or 32 mg of candesartan cilexetil and the adhering to non-active components: hydroxypropyl cellulose, lactose monohydrate, corn starch, glycerin, carboxymethylcellulose calcium, and magnesium stearate. Ferric oxide is added to the 8-mg, 16-mg, and 32-mg tablets as a colorant.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
2541C24H20N6O3440.5CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OCCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OInChI=1S/C24H20N6O3/c1-2-33-24-25-20-9-5-8-19(23(31)32)21(20)30(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-26-28-29-27-22/h3-13H,2,14H2,1H3,(H,31,32)(H,26,27,28,29)HTQMVQVXFRQIKW-UHFFFAOYSA-N2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid4.1440.15968852440.1596885211966002773300000001
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