Capecitabine
Summarized by Plex Health
Last Updated: 02 May 2022
"treatment of her2-positive metastatic breast cancer with lapatinib and capecitabine in the lapatinib expanded access programme, including efficacy in brain metastases--the uk experience.", by Sutherland S, Ashley S, Miles D, Chan S, Wardley A, Davidson N, Bhatti R, Shehata M, Nouras H, Camburn T, Johnston SR. fig3: Response of CNS metastases to lapatinib and capecitabine in the absence of previous whole-brain radiotherapy. This 61-year-old woman with HER2-positive breast cancer was diagnosed in 2002. Subsequently, she received three lines of trastuzumab-containing chemotherapy...
Capecitabine is used alone or in combination chemotherapy to deal with colon cancer, breast cancer, or colon cancer. Capecitabine is also being researched in the treatment of other types of cancer. Meaning from the NCI Drug Dictionary, Detailed scientific meaning and other names for this medicine. Drugs are typically examined to figure out if they can aid treat or prevent problems besides the ones they are approved for. This patient details sheet applies only to accepted uses the drug. Much of the information might also apply to unauthorized uses that are being examined. For Metastatic HER2-Positive Breast Cancer, New Treatments Emerge Altering Chemotherapy Improves Outcomes in Early-Stage Pancreatic Cancer.
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Sources:
https://www.mayoclinic.org/drugs-supplements/capecitabine-oral-route/description/drg-20062...
https://www.drugs.com/mtm/capecitabine.html
https://www.cancer.gov/about-cancer/treatment/drugs/capecitabine
Research Papers' Summaries
PubChem - CovalentUnitCount
(Table source)| CID | MolecularFormula | MolecularWeight | CanonicalSMILES | IsomericSMILES | InChI | InChIKey | IUPACName | XLogP | ExactMass | MonoisotopicMass | TPSA | Complexity | Charge | HBondDonorCount | HBondAcceptorCount | RotatableBondCount | HeavyAtomCount | IsotopeAtomCount | AtomStereoCount | DefinedAtomStereoCount | UndefinedAtomStereoCount | BondStereoCount | DefinedBondStereoCount | UndefinedBondStereoCount | CovalentUnitCount |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 60953 | C15H22FN3O6 | 359.35 | CCCCCOC(=O)NC1=NC(=O)N(C=C1F)C2C(C(C(O2)C)O)O | CCCCCOC(=O)NC1=NC(=O)N(C=C1F)[[email protected]]2[[email protected]@H]([[email protected]@H]([[email protected]](O2)C)O)O | InChI=1S/C15H22FN3O6/c1-3-4-5-6-24-15(23)18-12-9(16)7-19(14(22)17-12)13-11(21)10(20)8(2)25-13/h7-8,10-11,13,20-21H,3-6H2,1-2H3,(H,17,18,22,23)/t8-,10-,11-,13-/m1/s1 | GAGWJHPBXLXJQN-UORFTKCHSA-N | pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate | 0.6 | 359.14926359 | 359.14926359 | 121 | 582 | 0 | 3 | 7 | 7 | 25 | 0 | 4 | 4 | 0 | 0 | 0 | 0 | 1 |
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