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Chloroquine

Summarized by Plex Health
Last Updated: 02 May 2022
the anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in her2-positive breast cancer. "the anti-malarial chloroquine overcomes primary resistance and restores sensitivity to trastuzumab in her2-positive breast cancer.", by Cufí S, Vazquez-Martin A, Oliveras-Ferraros C, Corominas-Faja B, Cuyàs E, López-Bonet E, Martin-Castillo B, Joven J, Menendez JA. f3: Pharmacological ablation of the autophagy flux: Impact on the primary resistance to trastuzumab.(A). Representative images of untreated, trastuzumab (Tzb)-, chloroquine, and trastuzumab + chloroquine-treated JIMT-1 cell cultures (6 h) that were captured using different...

Chloroquine is used to treat or stop malaria, a disease brought on by parasites that go into the body with the bite of a mosquito. Chloroquine is not reliable against all strains of malaria, or against malaria in areas where the infection has been immune to a similar drug called hydroxychloroquine. Chloroquine may be used for functions not noted in this drug guide. Chloroquine can cause hazardous impacts on your heart, particularly if you additionally use specific other medications. Taking chloroquine long-lasting or at high doses may cause permanent damages to the retina of your eye that might proceed to long-term vision troubles. If you have a background of vision changes or damage to your retina, you might not be able to use chloroquine. If you have ever before had vision changes or damage to your retina, you may not be able to use chloroquine. High doses or long-lasting use chloroquine might cause irreversible damage to your retina. The risk of retinal damages is higher in people with pre-existing eye problems, kidney disease, or people that take tamoxifen. To deal with amebiasis: Chloroquine is given up a high starting dosage for 2 days adhered to by a smaller dose for 2 to 3 weeks. If the child gains or loses weight, your child's dose requirements might change. Call your medical professional as soon as possible if you have been revealed to malaria, or if you have fever or other symptoms of illness during or after a remain in an area where malaria is common.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
2719C18H26ClN3319.9CCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)ClCCN(CC)CCCC(C)NC1=C2C=CC(=CC2=NC=C1)ClInChI=1S/C18H26ClN3/c1-4-22(5-2)12-6-7-14(3)21-17-10-11-20-18-13-15(19)8-9-16(17)18/h8-11,13-14H,4-7,12H2,1-3H3,(H,20,21)WHTVZRBIWZFKQO-UHFFFAOYSA-N4-N-(7-chloroquinolin-4-yl)-1-N,1-N-diethylpentane-1,4-diamine4.6319.1815255319.181525528.230901382201010001
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