Clozapine

Summarized by Plex Health
Last Updated: 02 May 2022

Clozapine, an atypical antipsychotic drug, is a tricyclic dibenzodiazepine by-product. 8-chloro-11-5 H-dibenzo [b, e] [1,4] diazepine. The structural formula is. Clozapine is readily available in pale yellow tablets of 25 mg and 100 mg for oral administration. Active Ingredient: clozapine. Non-active Ingredients are colloidal silicon dioxide, corn starch, lactose monohydrate, magnesium stearate, mineral oil, povidone, salt starch glycolate and talc. Clozapine can cause severe heart issues. You might have withdrawal symptoms or other problems if you quit taking your medication throughout maternity. If you begin taking clozapine again after 2 or more day of rests the medicine, you might need to use a lower dosage than when you quit. First dosage: 12. 5 mg by mouth once or twice a day Titration and Maintenance dosage: May increase total daily dose in increments of 25 mg to 50 mg each day to a target dosage of 300 mg to 450 mg per day by the end of week 2. It is also used to lower risk of self-destructive behavior in patients with schizophrenia or schizoaffective disorder. Clozapine changes some of the chemicals in the brain that are thought to cause schizophrenia. This medicine needs to not be used to treat behavioral troubles in older adults with dementia. This medicine is only available through a limited program. You could be asked to review and sign papers that clarify how the medicine works and several of the unwanted effects.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
135398737C18H19ClN4326.8CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42CN1CCN(CC1)C2=NC3=C(C=CC(=C3)Cl)NC4=CC=CC=C42InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3QZUDBNBUXVUHMW-UHFFFAOYSA-N3-chloro-6-(4-methylpiperazin-1-yl)-11H-benzo[b][1,4]benzodiazepine3.1326.1298243326.129824330.944601312300000001
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