Summarized by Plex Health
Last Updated: 05 May 2022
mechanical cell competition kills cells via induction of lethal p53 levels. "mechanical cell competition kills cells via induction of lethal p53 levels.", by Wagstaff L, Goschorska M, Kozyrska K, Duclos G, Kucinski I, Chessel A, Hampton-O'Neil L, Bradshaw CR, Allen GE, Rawlins EL, Silberzan P, Carazo Salas RE, Piddini E. f1: Compaction of scribKD cells is both required and sufficient for their elimination.(a–c) Quantification showing growth rate of scribKD cells from time-lapse movies of: competition versus pure cultures (a), pure cultures in mock conditioned versus...

Last month, NCI released a competition to spur research in an area of wonderful public health interest: the genomic basis of breast cancer and breast cancer risk. The cutting-edge use of GWAS data can aim to new research directions that can better identify women at increased risk of breast cancer and overview efforts to enhance prevention and very early discovery, the competition coordinators think. A competition that motivates novel, cross-disciplinary research is a perfect way to assist generate advances in the understanding of the genetic basis of breast cancer risk, Dr. Gillanders claimed. Regardless of notable enhancements in the early discovery and therapy of breast cancer, it continues to be the 2nd most common cause of cancer fatality in U. S. women. Many epidemiologic research studies have highly suggested that genetic elements affect breast cancer risk, including the risk of specific types of breast cancer. Dr. Gillanders stated, the outcomes to date explain only a small section of the projected genetic contribution to breast cancer risk. The major goals of the U4C challenge, she proceeded, are to increase the number and diversity of minds tackling this challenging scientific trouble, shift the focus of evaluation from individual genetic variants to hereditary pathways, and discover the role of common hereditary variation in breast cancer wellness differences. Scientist wishing to take part in U4C can get access to a number of GWAS information collections, several of which are being offered for the very first time. These information represent hundreds of breast cancer patients and control subjects from ethnically diverse populations.

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