Congenital Adrenal Hyperplasia due to 11-beta-hydroxylase Deficiency

Summarized by Plex Health
Last Updated: 02 May 2022

Congenital adrenal hyperplasia due to 11-beta-hydroxylase deficiency is just one of a group of disorders that affect the adrenal glands. In people with CAH as a result of 11-beta-hydroxylase deficiency, the adrenal glands produce excess androgens, which are male sex hormones. There are 2 types of CAH due to 11-beta-hydroxylase deficiency, the non-classic form and the timeless kind. Women with the classic type of CAH because of 11-beta-hydroxylase deficiency have exterior genitalia that do not look clearly male or female. Furthermore, roughly two-thirds of individuals with the timeless type of CAH due to 11-beta-hydroxylase deficiency have high blood pressure. Women with the non-classic type of CAH as a result of 11-beta-hydroxylase deficiency have normal female genitalia. As affected women grow older, they may develop extreme body hair growth and irregular menstrual cycle. Males with the non-classic type of this problem do not typically have any signs or symptoms except for short stature. Hypertension is not a feature of the non-classic form of CAH due to 11-beta-hydroxylase deficiency.

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