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Coronavirus Mmr

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Last Updated: 02 July 2021

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FRIDAY, Sept. 4 2020-New clinical trial will try to determine whether measles, mumps and Rubella vaccine can protect health care workers from being infected with COVID-19. Hundreds of millions of people have received the MMR vaccine since it was developed nearly 50 years ago. It's usually given to children before age 6. Growing evidence suggests that vaccines may also prevent COVID-19. We know that the MMR vaccine is safe, and we think there are two main reasons that it could prevent COVID-19, say researcher Dr. Michael Avidan, head of the Department of Anesthesiology at Washington University School of Medicine Louis. First is this vaccine includes small amounts of live but very weakened measles, mumps and Rubella viruses, Avidan explained in a University news release. This type of vaccine appears to strengthen the body's immune response to infections in general, not just to viruses in that particular vaccine. The MMR vaccine may also work because it protects against viruses that are similar to Coronavirus. Researchers think that antibodies make To MMR vaccine might also fight SARS-CoV-2. In addition, researchers hope that the MMR vaccine might make cases of COVID-19 milder. The Trial is funded by a 9 million grant from the Bill and Melinda Gates Foundation, Wellcome Trust, Mastercard, and other public and philanthropic donors. Researchers hope to enroll as many as 30 000 health care workers around the world. Participants will be randomly selected to get the MMR vaccine or placebo. Most of those recruited for trial will receive booster, as they likely received vaccine as children. But in some countries where MMR vaccine isn't widely give, health care workers may be receiving vaccine for the first time, researchers note. Countries involved in study include Canada, Ghana, Ireland, South Africa, Uganda, United Kingdom, United States, Zambia and Zimbabwe. Each study participant will be followed for five months, and the entire trial is expected to last about a year, researchers say. Scientists at University College London will compile data from the trial.

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Abbreviations

The recent emergence of severe acute respiratory syndrome coronavirus-2, cause of coronavirus Disease, is wreaking havoc due to widespread dissemination throughout the world. On 11 March 2020, WHO formally declared that global pandemic and by the end of August 2020, almost 25 million cases and over 800 000 deaths had been reported worldwide involving all continents, except Antarctica. Strategies to identify cases and limit spread by widespread testing and physical distancing have been challenging to implement, healthcare and public health systems have been overwhelm, resulting in continued escalation in many countries and profound effects on lives and livelihoods. While the majority of people are either asymptomatic or experience mild respiratory infection, ~20 % of cases are more severe and require hospital admission. Report mortality rates vary by geographic region, ranging from almost 20 % in France to < 1 % in many other countries. This wide discrepancy suggests selection bias due to differences in local testing strategies and capacity, consistent with differences in health system capacity, population demographics and other health determinants. Certain groups, such as the elderly and those with particular comorbidities are more likely to die of COVID-19. Healthcare workers in particular have experienced significant morbidity and mortality from COVID-19, causing clear psychological impacts and threatening delivery of healthcare services. There is no known effective treatment for this virus and currently no available Vaccine, with the result being that SARS-CoV-2 continues to spread throughout the virus naive population of the world. The urgent need for effective SARS-CoV-2 vaccines cannot be overstate. Immunization can not only protect individuals but also, if provided to enough people in timely way with partially protective vaccines, induce sufficient herd immunity to curtail spread of this virus and reduce morbidity and mortality across the globe. The race to develop safe and effective vaccines has seen SARS-CoV-2 candidate vaccines develop at a scale and pace never imagined before: currently almost 200 potential vaccines are in various stages of development. A range of Vaccine design approaches and platforms have been employ. However, since > 95 % of candidate vaccines typically fail, it is expected that the eventual number of successful vaccines may be only a handful. They may also become available in different time frames and suitable for use in different populations. Most Vaccine Candidates are currently in preclinical Trials, but a number have entered Phase 1 or Phase 1 / 2 studies, with plans to rapidly scale up to Phase 2 and 3. Trials are being conducted at pandemic speed and using novel designs. This early success has already seen cooperation and collaboration as well as significant funding across the globe. For example, Coalition for Epidemic Preparedness Innovations, not-for-profit global Coalition launched in 2017 to deal with the worldwide threat of Epidemic outbreaks, is playing a pivotal role in supporting many of frontrunner vaccines. Herein, we review what is currently known about immune response to SARS-CoV-2 and various vaccine platforms being used to develop SARS-CoV-2 vaccines.

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* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Fire up the humidifier

CLEVELAND, Ohio-Humidity could be helpful in relieving symptoms of Coronavirus, as well as preventing it from spreading, if evidence from flu research is indication. Like many aspects of COVID-19, there is not much known yet about its connection with humidity. Most of the research on this topic has to do with influenza, because of its reemergence during winter and because of the negative impact it has during colder months, Dr. Amy Edwards, infectious Disease specialist at UH Rainbow Babies and Childrens Hospital say. It is probably specific to some viruses, Edwards say. Whether this Coronavirus is one-I guess well see in a couple months. Humidity affects the flu in two ways. Studies have shown that water in the air could slow the spread of Influenza. I know for influenza it kind of is intuitively opposite to what you might think, Dr. Harry Kestler, microbiology professor at Lorain County Community College, say. As humidity goes down, viruses actually do better. So in winter, you wonder why is it always winter In homes, in winter, it tends to be dry. And low humidity can dry out mucus that normally coats your nose and airways, making it easier to get infect, according to CLEVELAND Clinic. It can also dry out skin on your lips and your eyes. Heating systems can make the air in homes during winter incredibly dry, Kestler say. That is why people often use humidifiers during winter. The majority of adverse health effects caused by Relative Humidity would be minimized by maintaining indoor levels of between 40 and 60 percent, according to an article in Environmental Health Perspectives. The Centers for Disease Control and Prevention recommend humidifier to help fight symptoms like cough and sore throat for other common coronaviruses, but hasnt recommend it for this year novel Coronavirus. Kestler recommends running a hot shower to breathe in steam. That will hydrate your nose and throat. Theres always the time-old method of boiling a pot of water and carefully breathing in that steam as well. But Edwards warns against boosting humidity too high, which can spur mold growth.-Coping with Coronavirus: Guide aims to ease fear of pandemic Disease-MetroHealth Dr. Amy Ray offers helpful Coronavirus advice in video-cuyahoga Countys chief judge declares judicial Emergency, ' announces further restrictions to fight spread of novel Coronavirus-cuyahoga County Probate Court suspend issuance of marriage licenses-FAQ: Everything you need to know about getting Ohio unemployment amid Coronavirus outbreak

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Tamp down aerosols

NEW YORK at University of Maryland lab, people infected with the NEW Coronavirus take turns sitting on chair and putting their face into big end of a large cone. They recite alphabet and sing or just sit quietly for half an hour. Sometimes they cough. Cone suck up everything that comes out of their mouths and noses. It is part of a device called Gesundheit II that is helping scientists study big question: Just how does the virus that caused COVID-19 spread from one person to another? It is clearly a hitchhike on small liquid particles sprayed out by an infected person. People expel particles while coughing, sneezing, singing, shouting, talking and even breathing. But drops come in a wide range of sizes, and scientists are trying to pin down how risky various kinds are. The answer affects what we should all be doing to avoid getting sick. That is why it was thrust into the headlines a few days ago when the US Health agency appeared to have shifted its position on the issue, but later said it had published NEW language in error. The recommendation to stay at least 6 feet apart, some authorities cite about half that distance, is based on the idea that larger particles fall to the ground before they can travel very far. They are like droplets in a spritz of window cleaner, and they can infect somebody by landing on their nose, mouth or eyes, or maybe being inhale. But some scientists are now focusing on tinier particles, ones that spread more like cigarette smoke. Those are carried by wisps of air and even upward drafts caused by the warmth of our bodies. They can linger in the air for minutes to hours, spreading throughout the room and build up if ventilation is poor. Potential risk comes from inhaling them. Measles can spread this way, but the NEW Coronavirus is far less contagious than that. For these particles, called aerosols, 6 feet is not the magic distance, says Linsey Marr, leading researcher WHO is studying them at Virginia Tech in Blacksburg. But she says it is still important to keep one distance from others, farther better, because aerosols are most concentrated near source and pose bigger risk at close range. Public health agencies have generally focused on larger particles of Coronavirus. That prompted more than 200 other scientists to publish pleas in July to pay attention to potential risk from aerosols. The World Health Organization, which had long dismissed danger from aerosols except in case of certain medical procedures, later said that Aerosol transmission of Coronavirus could be ruled out in cases of infection within crowds and poorly ventilated indoor spaces. The issue drew attention recently when the US Centers for Disease Control and Prevention posted and then deleted statements on its website that highlighted the idea of Aerosol spread.

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LETTER

The Centers for Disease Control and Prevention is closely monitoring developments around outbreak of respiratory illness caused by Novel Coronavirus first identified in Wuhan, Hubei Province, China. Chinese authorities identified a new Coronavirus, which has resulted in hundreds of confirmed cases in China, including cases outside Wuhan City, with additional cases being identified in a growing number of countries internationally. The first case in the United States was announced on January 21 2020. There are ongoing investigations to learn more. For more information, visit the CDC website on 2019 Novel Coronavirus. Information and updates about 2019-nCoV in Maryland including up-to-date testing and laboratory-confirm case numbers are available at: https: / Health. Maryland. Gov / Coronavirus. Information from Maryland Department of Health Laboratories, including testing instructions, is available here: https: / Health. Maryland. Gov / Laboratories / Pages / Novel-Coronavirus. Aspx. This chart is from the Crisis / Alternate Strategies section of CDC Strategies for Optimizing Supply of N95 Respirators guidance.

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Advice for travellers

The CDC recommends that everyone wear a mask over their nose and mouth when in public, including on public transportation and in transportation hubs such as airports and stations. Masks slow the spread of COVID-19 because they help keep people who are infected from spreading respiratory droplets to others when they cough, sneeze, or talk. Medical masks and N-95 respirators are for healthcare workers and other first responders, as recommended by current CDC guidance. Children younger than 2 years old. Anyone who has trouble breathing Anyone who is unconscious, incapacitated, or otherwise unable to remove mask without help yes. Travel increases your chances of getting and spreading COVID-19. Before you travel, learn if COVID-19 is spreading in your local area or in any of the places you are going. Traveling to visit family may be especially dangerous if you or your loved ones are more likely to get very ill from COVID-19. People at higher risk for severe illness need to take extra precautions. For more considerations see webpage Coronavirus in United StatesConsiderations for Travelers. Yes. Going camping at a time when much of the United States is experiencing Community spread of COVID-19 can pose a risk to you if you come in close contact with others or share public facilities at campsites or along trails. Exposure may be especially unsafe if you are more likely to get very ill from COVID-19 and are planning to be in remote areas, without easy access to medical care. Also, be aware that many local, state, and national public parks have been temporarily closed due to COVID-19. Follow these actions when visiting park. Travel increases your chance of getting and spreading COVID-19. COVID-19 risk in most countries is high, and travelers should avoid nonessential travel to high-risk destinations. Travelers at increased risk for severe illnesses should consider postponing all travel, including essential travel, to high-risk destinations. To check destinations ' COVID-19 risk level, see COVID-19 Travel Recommendations by Destination. Some healthcare systems are overwhelmed and there may be limited access to adequate medical care in affected areas. Many countries are implementing travel restrictions and mandatory quarantines, closing borders, and prohibiting non-citizens from entry with little advance notice. If you choose to travel internationally, your travel plans may be disrupt. If you get sick or are exposed to person with COVID-19 during your trip, you may be isolated or quarantined and your return to the United States may be delay. The CDC also recommends all travelers defer all cruise ship travel worldwide. Yes. Air travel requires spending time in security lines and airport terminals, which can bring you in close contact with other people and frequently touch surfaces. Most viruses and other germs do not spread easily on flights because of how air circulates and is filtered on airplanes. However, social distancing is difficult on crowded flights, and you may have to sit near others, sometimes for hours. This may increase your risk for exposure to viruses that cause COVID-19.

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* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Training the immune system

COVID-19 vaccine trials are underway in unprecedented fashion. But lately, questions about the integrity of Operation Warp Speed have started to linger. The Vaccine availability deadline prior to phase 3 data has not help, and many think that immunity, while feasible, is still distant. While awaiting proof of vaccine reliance, Immune training could act as a stopgap. The Concept of Trained immunity is based on how innate Immune system, composed of monocytes, macrophages, and natural killer cells, can display higher than usual response when they encounter various pathogens other than ones against which Immune response was initiate. Thus, adding non-specific partial defense mechanism against many different infectious agents. Simply put, it refers to the ability of the Immune system to produce adequate and early combative response against pathogen even if it has not been exposed to it in the past. Immune training appears to occur when various recent vaccinations have left more activated innate immune system. Much like rev-up car engine right before the race start. This is different from adaptive immunity, which form basis for Vaccination. Adaptive immunity follows innate Immune response during infection and creates Microbe-specific Immune response. Adaptive immunity utilizes T cells and B cells, which eliminate pathogens and leave behind memory T cells, which can facilitate faster Immune response if exposure to the same pathogen recurs. The Theory of Immune training also has its foundation in how novel Coronavirus behaves in children. There are many plausible expletives about severe infection, or lack thereof, in children. One discuss that exposure to common cold coronaviruses, which is more common in children, may help develop cross-reacting antibodies resulting in a better ability to fight novel Coronavirus. Another discussed possible presence of higher level of bystander immunity due to recent vaccinations in children, and hence their immune systems are better prepared for quicker antibody response against the novel Coronavirus. The BCG vaccine, used for tuberculosis, has historically been shown to decrease 30 % of infections from various other pathogens within the first year of its administration. Recent interim analysis of the ACTIVATE trial showed a 53 % decrease in the incidence of all new infections with BCG Vaccination. Specifically, with respect to COVID-19, analysis utilizing European data has suggested that for every 10 % increase in degree of universal BCG Vaccination deployment in a country, COVID-19 mortality was reduced by 10. 4 %. Consequently, multiple trials to assess prevention of COVID-19 by BCG vaccine are underway all over the globe. An ongoing American study is addressing the ability of the BCG vaccine in mounting defense against SARS-COV2 amongst health care workers. Researchers have also presented hypothesis suggesting the potential role of booster dose of MMR vaccine in the elderly to prevent severe COVID-19 sepsis. MMR is like BCG, as it is live attenuated vaccine. It can also theoretically rely on non-specific innate Immune response to potentially prevent further unrelated infections from various pathogens.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

The evidence behind the theory

In a video that has exploded on social media in the past few days, virologist Judy Mikovits claims the new Coronavirus is being wrongly blamed for many deaths. She makes head-scratching assertions about virusfor instance, that it is activated by face masks. Mikovits also accuse Anthony Fauci, head of the US National Institute of Allergy and Infectious Diseases and prominent member of White Houses Coronavirus Task Force, of being responsible for the deaths of millions during the early years of the HIV / AIDS pandemic. The video claims Mikovits was part of a team that discovered HIV, revolutionized HIV treatment, and was jailed without charges for her scientific positions. Science fact-checked video. None of these claims are true. The Video is an excerpt from the forthcoming movie Plandemic, which Promise to expose the scientific and political elite who run the scam that is our global health system. YouTube, Facebook, and other platforms have taken down videos because of inaccuracies. It keeps resurfacing, including on the Plandemic website, which, in an effort to bypass gatekeepers of free speech, invites people to download video and repost it. Mikovits started her career as a lab technician at the National Cancer Institute in 1988. She became a scientist and obtained ph. D in biochemistry and molecular biology from George Washington University in 1991. By 2009, she was Research director at Whittemore Peterson Institute, private Research center in Reno, Nevada, but she remains largely unknown to the scientific community. That year, however, she co-authored a paper in Science that suggested an obscure agent named xenotropic murine leukemia virus-related virus cause chronic fatigue syndrome. The cause of CFS, also called myalgic encephalomyelitis, has long remained elusive, and the disease has been neglected by Science. Study create hope that CFS might become treatable with antivirals. Some patients even begin to take antiretroviral drugs used by HIV-infected people. But paper also creates worries that XMRV might spread via blood supply. Other researchers soon questioned the findings, and over the next 2 years, paper claims fell apart. Researchers show that XMRV was created accidentally in the lab during mouse experiments; It may never have infected any humans. Authors first retract two figures and a table from paper in October 2011. Around the same time, study by several labs, including WPI itself, showed findings couldnt be replicate. Two months later, entire Science paper was retract. Mikovits refused to sign a retraction notice, but she took part in another major replication effort. That 2. 3 million study, led by Ian Lipkin of Columbia University and funded by the National Institutes of Health, was the definitive answer, Mikovits said at a September 2012 press conference where results were announce. A rigorous study looked for XMRV in blinded blood samples from nearly 300 people, half of whom had the disease, and none had the virus. There is no evidence that XMRV is a human pathogen, Mikovits concede.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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