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Covid 19 Mmr Vaccine

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Last Updated: 02 July 2021

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General | Latest Info

Friday, Sept. 4 2020 - A new clinical trial will try to determine whether Measles, mumps and Rubella Vaccine can protect health care workers from being infected with COVID - 19. Hundreds of millions of people have received MMR Vaccine since it was developed nearly 50 years ago. It's usually given to children before age 6. Growing evidence suggests that vaccines may also prevent COVID - 19. We know that MMR Vaccine is safe, and we think there are two main reasons that it could prevent COVID - 19, say researcher Dr. Michael Avidan, head of the Department of Anesthesiology at Washington University School of Medicine Louis. First is this vaccine includes small amounts of live but very weakened Measles, mumps and Rubella viruses, Avidan explains in a University news release. This type of vaccine appears to strengthen the body's immune response to infections in general, not just to viruses in that particular vaccine. Mmr Vaccine may also work because it protects against viruses that are similar to Coronavirus. Researchers think that antibodies made to MMR Vaccine might also fight SARS - CoV - 2. In addition, researchers hope that MMR Vaccine might make cases of COVID - 19 milder. The Trial is funded by a 9 million grant from the Bill and Melinda Gates Foundation, Wellcome Trust, Mastercard, and other public and philanthropic donors. Researchers hope to enroll as many as 30 000 health care workers around the world. Participants will be randomly selected to get MMR Vaccine or placebo. Most of those recruited for trial will receive booster,s as they likely received vaccine as children. But in some countries where MMR Vaccine isn't widely give, health care workers may be receiving vaccine for the first time, researchers note. Countries involved in study include Canada, Ghana, Ireland, South Africa, Uganda, United Kingdom, United States, Zambia and Zimbabwe. Each study participant will be followed for five months, and the entire trial is expected to last about a year, researchers say. Scientists at University College London will compile data from the trial.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Training the immune system

As companies scramble to develop vaccines against SARS - CoV - 2 virus, team of husband and wife researchers have found that measles, mumps, rubella vaccines can reduce symptoms of COVID - 19. Finding does eliminate the need for a specific COVID - 19 vaccine, but offers at least some protection for healthcare workers and other individuals WHO are at high risk of contracting COVID - 19. Reporting in American Society for Microbiology, Paul Fidel Jr., Ph. D, associate Dean of Research at Louisiana State University Health School of Dentistry, and his wife, Mari Noverr, ph. D, Professor of Microbiology & Immunology at Tulane University School of Medicine, found that vaccination against MMR by immunocompetent individuals is not only safe, but also may be effective against SARS - CoV - 2 virus. More specifically, Noverrs lab, in collaboration with Fidel, found that vaccination with live attenuate fungal strain of MMR vaccine generate response from innate Immune system against lethal polymicrobial sepsis. That protection was mediated by long - live myeloid - derive suppressor cells that in multiple experimental models had inhibited septic inflammation and prevented death. Therefore, researchers suggest that MMR inoculation also induces MDSCs and thus inhibits or at least reduces severe lung inflammation or sepsis associated with progression of COVID - 19. The ability of live attenuated vaccines to train the immune system against non - target pathogens by training the host system against a variety of infections is a key feature of this approach. Evidence of its efficacy is growing. Traditional Vaccines seek to ACTIVATE adaptive Immune system by causing T - and B - lymphocytes to recognize specific pathogen. Then when a similar pathogen is encountered later, adaptive Immune system will remember that pathogen and launch defense. Innate Immune system works differently. It recognizes pathogens through a system of pattern recognition receptors that quickly ACTIVATE host defense. Innate Immune systems do not, however, possess immunologic memory. During the past several years, clinical trials have shown that innate immune cells - monocytes, macrophages and NK cells, for example - can confer protection from certain infections independently of lymphocytes. Notably, this system provides nonspecific protection against infections unrelated to the target pathogen of a particular vaccine. Milder symptoms seen in 955 sailors on USS Roosevelt, WHO tested positive for COVID - 19, are real - world illustration of this effect. Mmr vaccinations are given to all US Navy recruits, researchers point out. Additional data note correlation between people in geographical locations WHO routinely receive MMR vaccine and reduce COVID - 19 death rates. Research shows that countries with recent vaccination campaigns against measles - rubella have fewer COVID - 19 deaths. There is further correlation between those born after about 1971, when MMR Vaccination became widespread, and low incidence of COVID - 19. Hong Kong, for example, has 1 128 cases as of June 19, and 1. 074 WHO had recovered from COVID - 19. Only four people die. That fatality rate of 0. 4% of the population of 7.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

The evidence behind the theory

Fidel and Noverr say the MMR vaccine could induce MDSCs in people with COVID - 19, which could help them to fight lung inflammation and sepsis associated with most severe forms of disease. As evidence for this, they cite a recent case where 955 sailors on USS Roosevelt tested positive for COVID - 19 but only experienced mild symptoms. Researchers suggest that this may be because all US Navy recruits receive MMR vaccination. However, it is likely that age and fitness of sailors also play a part in their recovery. Other evidence in support of the connection between the MMR vaccine and COVID - 19 recovery come from epidemiological data. People WHO live in areas that routinely receive MMR vaccine have lower COVID - 19 death rates. Covid - 19 is also less likely to affect children, which may also have links to vaccination. While age is a known risk factor for COVID - 19 severity, fact that many children have had more recent exposure to live attenuated vaccines could also play a role in their protection, article suggest.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Progressing to clinical trial

Now, in collaboration with Pirbright Institute in UK, Jenner Institute has tested a vaccine, called ChAdOx1 nCoV - 19 vaccine, in pigs and found that two doses create greater antibody response than one dose. According to Pirbright Institute, phase I of human clinical trials has already start. Researchers are testing a single dose of ChAdOx1 nCoV - 19 because research in macaque monkeys shows that single immunization with vaccine protects against lung disease. Researchers are now recruiting volunteers for the next phase of human clinical trials. The fact that two doses prove more protective than one in pigs is important because it suggests that the same might be true in humans. It also suggests that if results of human clinical trials are underwhelming at one dose, upping intervention to two doses may yield better outcomes. The pig has proven to be a valuable model for testing human vaccines for other diseases to give indication of type of immune response induced and testing different doses, Prof. Charleston continue. Pigs are more physiologically similar to humans than some other animal models. For example, their body weight and metabolic rate and are more accessible than studies using nonhuman primates.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Abbreviations

Most children are perfectly well after having Dose of Measles, mumps and Rubella Vaccine. Serious problems with MMR Vaccine are extremely rare. However: some children develop mild raised temperature and faint rash 7 - 10 days later. This should only last for 2 - 3 days and is of no concern. Mild reactions such as slight fever, mild sore throat and joint pains sometimes occur about 1 - 3 weeks after injection. These soon subside and are of no consequence. Few children develop mild swollen faces about three weeks later. Any swelling will gradually go down. None of these reactions is infectious or serious. If necessary, you can give paracetamol or ibuprofen to ease pain and fever. Any reaction to one vaccine is much less after the second vaccine is give.


What does MMR mean?

The first dose of vaccine is usually given between 12 and 13 months. It is usually given at the same time as the Hib / MenC vaccine - this stands for Haemophilus influenzae type b / meningitis C and pneumoccocal vaccine. The second dose is usually given at age 3 years and 4 months to 5 years at the same time as DTaP / IPV injection. Even if the dose of MMR is delayed for any reason, it can still be given at a later age. If necessary, MMR vaccine can be given at any age.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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