Cytogenetically Normal Acute Myeloid Leukemia

Summarized by Plex Health
Last Updated: 02 May 2022
high expression of runx1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia. "high expression of runx1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia.", by Fu L, Fu H, Tian L, Xu K, Hu K, Wang J, Wang J, Jing H, Shi J, Ke X. F4: Genome-wide gene/microRNA-expression profiles associated with RUNX1 expression(A) Expression heat map of associated genes (B) The list of associated genes. (C) Expression heat map of associated microRNAs. (D) The list of associated microRNAs....

Cytogenetically normal acute myeloid leukemia is one type of a cancer of the blood-forming tissue called acute myeloid leukemia. In normal bone marrow, very early blood cells called hematopoietic stem cells become several types of blood cells: leukocyte that protect the body from infection, red blood cells that lug oxygen, and platelets that are associated with blood clotting. In acute myeloid leukemia, the bone marrow makes large numbers of abnormal, premature leukocyte called myeloid blasts. Rather of developing into normal white blood cells, the myeloid blasts turn into cancerous leukemia cells. People with CN-AML have a lack of all types of fully grown blood cells: a scarcity of leukocyte causes increased vulnerability to infections, a low variety of red cell causes tiredness and weak point, and a reduction in the amount of platelets can cause very easy bruising and abnormal blood loss. Other symptoms of CN-AML might consist of fever and fat burning.

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