Dabigatran

Summarized by Plex Health
Last Updated: 02 May 2022
dabigatran and apolipoprotein b. "dabigatran and apolipoprotein b.", by ten Cate H. HEARTJNL2015308575F1: Thrombin is involved in many pathways in atherogenesis (including inflammation and proliferation); blocking thrombin's catalytic activity with dabigatran will also diminish the potential of thrombin to bind and activate protease activated receptor-1 (PAR-1), resulting...

Dabigatran is used to lower the risk of stroke triggered by a blood embolism in people with a heart rhythm disorder called atrial fibrillation. When the atrial fibrillation is not created by a heart shutoff issue, dabigatran is used. Dabigatran is also used after hip substitute surgical treatment to stop a type of blood embolism called deep capillary thrombosis, which can lead to embolism in the lungs. Dabigatran is used to deal with DVT or pulmonary blood clot, and to lower your risk of having a repeat DVT or PE. Dabigatran can cause you to bleed more quickly. Many other drugs can increase your risk of bleeding when used with dabigatran. If you undertake a spinal tap or obtain spinal anesthetic, Dabigatran can cause a very significant blood embolisms around your spinal cord. Inform your doctor if you are pregnant or if you become pregnant. Taking dabigatran throughout pregnancy might cause blood loss in the mommy or the newborn. The risk of blood clots is higher during pregnancy. The benefit of stopping an embolism may exceed any dangers to the baby. You may take dabigatran with or without food. Due to the fact that dabigatran maintains your blood from coagulating to stop undesirable blood embolisms, this medicine can also make it less complicated for you to hemorrhage, even from a minor injury such as a loss or a bump on the head. Your kidney function may require to be examined prior to and during treatment with dabigatran. Open a new bottle only nevertheless the capsules in the old container are gone. Do not place dabigatran pills into a daily tablet box or tablet organizer.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
216210C25H25N7O3471.5CN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)NCN1C2=C(C=C(C=C2)C(=O)N(CCC(=O)O)C3=CC=CC=N3)N=C1CNC4=CC=C(C=C4)C(=N)NInChI=1S/C25H25N7O3/c1-31-20-10-7-17(25(35)32(13-11-23(33)34)21-4-2-3-12-28-21)14-19(20)30-22(31)15-29-18-8-5-16(6-9-18)24(26)27/h2-10,12,14,29H,11,13,15H2,1H3,(H3,26,27)(H,33,34)YBSJFWOBGCMAKL-UHFFFAOYSA-N3-[[2-[(4-carbamimidoylanilino)methyl]-1-methylbenzimidazole-5-carbonyl]-pyridin-2-ylamino]propanoic acid1.7471.20188768471.2018876815075704793500000001
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