Dandy-Walker malformation influences brain development, mainly advancement of the brain, which is the part of the brain that coordinates movement. The right and left sides of the brain might be small as well. In affected individuals, a fluid-filled cavity in between the brainstem and the cerebellum and the part of the head which contains the cerebellum and the brainstem are unusually large. Most of people with Dandy-Walker malformation, symptoms and signs triggered by abnormal brain advancement are present at birth or develop within the first year of life. Some children have an accumulation of fluid in the brain that may cause increased head dimension. As much as half of affected people have intellectual handicap that varies from mild to serious, and those with normal intelligence may have learning handicaps. Children with Dandy-Walker malformation often have postponed growth, specifically a delay in motor skills such as crawling, walking, and working with activities. People with Dandy-Walker malformation may experience muscle mass tightness and partial paralysis of the lower limbs, and they might have seizures. Much less frequently, other brain irregularities have been reported in people with Dandy-Walker malformation. In 10 to 20 percent of people with Dandy-Walker malformation, signs and symptoms of the condition do not show up till late childhood years or into the adult years. Hardly ever, people with Dandy-Walker malformation have no health and wellness troubles related to the problem. Problems associated with hydrocephalus or complications of its treatment are the most common cause of death in people with Dandy-Walker malformation.
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