Docetaxel

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Last Updated: 05 May 2022
potentiation of antitumour activity of docetaxel by combination with trastuzumab in a human prostate cancer xenograft model and underlying mechanisms. "potentiation of antitumour activity of docetaxel by combination with trastuzumab in a human prostate cancer xenograft model and underlying mechanisms.", by Legrier ME, Oudard S, Judde JG, Guyader C, de Pinieux G, Boyé K, de Cremoux P, Dutrillaux B, Poupon MF. fig2: Histological features of PAC120, HID25 and HID28 xenografts (HES staining, × 200 magnification). Left panels, untreated tumours; middle panels, docetaxel-treated tumours; right panels, docetaxel plus trastuzumab-treated tumours. (A) PAC120 tumours were characterised by a...

Docetaxel is an antineoplastic agent belonging to the taxoid family. The chemical name for docetaxel is -Ncarboxy-3phenylisoserine, N-tert-butyl ester, 13-ester with 5 -20-epoxy-1,2,47,10,13 -hexahydroxytax-11-en-9one 4-acetate 2-benzoate. Docetaxel has the following structural formula: Docetaxel is a white to almost-white powder with an empirical formula of C43H53NO14, and a molecular weight of 807. 88. Each mL has 10 mg docetaxel, 260 mg polysorbate 80 NF, 4 mg anhydrous citric acid USP, 23% v/v dehydrated alcohol USP, and polyethylene glycol 300 NF. Docetaxel Injection is available in single-dose vials including 20 mg docetaxel, and multiple-dose vials consisting of 80 mg or 160 mg docetaxel. Docetaxel can cause serious side effects including death, especially if you get high doses, if you have liver disease, or if you have non-small cell lung cancer and you have been treated in the past with chemotherapy which contains platinum. Making use of docetaxel might increase your risk of developing other types of cancer. If the papa or the mother is utilizing this medication, Docetaxel can cause or hurt an expected child birth problems. If it obtains on your skin during an IV mixture, Docetaxel can be harmful. Interpretation from the NCI Drug Dictionary, Detailed scientific definition and other names for this drug. If they can help treat or avoid conditions other than the ones they are authorized for, drugs are commonly studied to locate out. This patient details sheet applies only to authorized uses of the drug. Much of the information may additionally use to unapproved uses that are being examined. Hormone Therapy for Prostate Cancer. Long-Term Nerve Damage Possible after Chemotherapy for Breast Cancer.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
148124C43H53NO14807.9CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)OCC1=C2[[email protected]](C(=O)[[email protected]@]3([[email protected]](C[[email protected]@H]4[[email protected]]([[email protected]]3[[email protected]@H]([[email protected]@](C2(C)C)(C[[email protected]@H]1OC(=O)[[email protected]@H]([[email protected]](C5=CC=CC=C5)NC(=O)OC(C)(C)C)O)O)OC(=O)C6=CC=CC=C6)(CO4)OC(=O)C)O)C)OInChI=1S/C43H53NO14/c1-22-26(55-37(51)32(48)30(24-15-11-9-12-16-24)44-38(52)58-39(3,4)5)20-43(53)35(56-36(50)25-17-13-10-14-18-25)33-41(8,34(49)31(47)29(22)40(43,6)7)27(46)19-28-42(33,21-54-28)57-23(2)45/h9-18,26-28,30-33,35,46-48,53H,19-21H2,1-8H3,(H,44,52)/t26-,27-,28+,30-,31+,32+,33-,35-,41+,42-,43+/m0/s1ZDZOTLJHXYCWBA-VCVYQWHSSA-N[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4-acetyloxy-1,9,12-trihydroxy-15-[(2R,3S)-2-hydroxy-3-[(2-methylpropan-2-yl)oxycarbonylamino]-3-phenylpropanoyl]oxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate1.6807.34660536807.346605362241660051413580111100001
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