Dofetilide

Summarized by Plex Health
Last Updated: 02 May 2022
comprehensive t wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil. "comprehensive t wave morphology assessment in a randomized clinical study of dofetilide, quinidine, ranolazine, and verapamil.", by Vicente J, Johannesen L, Mason JW, Crumb WJ, Pueyo E, Stockbridge N, Strauss DG. fig04: Lead V3 of median beats of time‐matched placebo (gray), dofetilide (black), quinidine (orange), ranolazine (blue), and verapamil (green). Top panel (A): ECGs at 0.5, 2.5, 4, and 12 hours post‐dose from a woman with...

Dofetilide is a heart rhythm medicine, also called an antiarrhythmic. Dofetilide is used to aid keep the heart beating normally in people with specific heart rhythm disorders of the room. Dofetilide is used in people with atrial fibrillation or atrial flutter. Dofetilide may be used for functions not noted in this medicine overview. If you have serious kidney disease or a history of Long QT disorder, you need to not take dofetilide. Severe medicine interactions can occur when specific medications are used together with dofetilide. Inform each of your doctor about all medicines you use now, and any medicine you start or stop making use of. When you first start taking dofetilide, you will require to spend at least 3 days in a healthcare facility setting. This is so your heart rhythm and kidney function can be monitored in situation the medication causes major side effects. It is not understood whether dofetilide will harm an expected infant. It is not understood whether dofetilide enters breast milk or if it could harm a nursing infant. You will need to spend a minimum of 3 days in a healthcare facility setup when you first begin taking dofetilide. This is so your heart rhythm and kidney function can be kept an eye on in situation the medication causes serious side effects. You might take dofetilide with or without food. Your kidney function might additionally require to be consulted constant blood tests. Skip the missed dose and take your next dose at the typical time to remain on schedule.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
71329C19H27N3O5S2441.6CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)CCN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)CInChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3IXTMWRCNAAVVAI-UHFFFAOYSA-NN-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide1.8441.13921332441.13921332122672028112900000001
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