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Dolutegravir

Summarized by Plex Health
Last Updated: 02 May 2022
dolutegravir interactions with hiv-1 integrase-dna: structural rationale for drug resistance and dissociation kinetics. "dolutegravir interactions with hiv-1 integrase-dna: structural rationale for drug resistance and dissociation kinetics.", by DeAnda F, Hightower KE, Nolte RT, Hattori K, Yoshinaga T, Kawasuji T, Underwood MR. pone-0077448-g002: Structural models of HIV-1 integrase with U5 LTR DNA and (A, B) raltegravir, (C) elvitegravir or (D) dolutegravir.For raltegravir, the terminal 3′ adenylate is depicted in 2 distinct conformations: panel 2A shows the published...

Dolutegravir is an antiviral medication that is used with other medicines to treat HIV, the virus that can cause the acquired immunodeficiency disorder. Dolutegravir might additionally be used for functions not listed in this drug guide. If you are taking dofetilide, you need to not use dolutegravir. Taking dolutegravir during the first trimester of maternity might cause birth flaws. You ought to not use dolutegravir if you dislike it, or if you are also taking dofetilide. Dolutegravir may harm an expected baby if you take the medication at the time of conception or throughout the first 12 weeks of maternity. Use effective birth control to avoid pregnancy, and inform your physician if you conceive. HIV can be passed to your child if the virus is not controlled during pregnancy. Women with HIV or AIDS must not nurse. Even if your baby is birthed without HIV, the virus may be passed to the baby in your breast milk. You might take dolutegravir with or without food. The dolutegravir regular tablet and dispersible tablet can not be used in the same dosages. Avoid medicine mistakes by constantly examining the medicine you receive at the drug store. If the child gains or loses weight, your child's dose needs may change. If you've ever had liver disease B, utilizing dolutegravir can cause this virus to come to be active or get worse. You may require constant liver function tests while making use of dolutegravir and for a number of months after you quit. Use all HIV medications as routed and read all drug overviews you get. Everyone with HIV should remain under the treatment of a physician.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
54726191C20H19F2N3O5419.4CC1CCOC2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)OC[[email protected]@H]1CCO[[email protected]@H]2N1C(=O)C3=C(C(=O)C(=CN3C2)C(=O)NCC4=C(C=C(C=C4)F)F)OInChI=1S/C20H19F2N3O5/c1-10-4-5-30-15-9-24-8-13(17(26)18(27)16(24)20(29)25(10)15)19(28)23-7-11-2-3-12(21)6-14(11)22/h2-3,6,8,10,15,27H,4-5,7,9H2,1H3,(H,23,28)/t10-,15+/m1/s1RHWKPHLQXYSBKR-BMIGLBTASA-N(3S,7R)-N-[(2,4-difluorophenyl)methyl]-11-hydroxy-7-methyl-9,12-dioxo-4-oxa-1,8-diazatricyclo[8.4.0.03,8]tetradeca-10,13-diene-13-carboxamide2.4419.12927704419.1292770499.282902833002200001
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