Duloxetine

Summarized by Plex Health
Last Updated: 02 May 2022
chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use. "chronic treatment with prazosin or duloxetine lessens concurrent anxiety-like behavior and alcohol intake: evidence of disrupted noradrenergic signaling in anxiety-related alcohol use.", by Skelly MJ, Weiner JL. fig06: Chronic treatment with prazosin or duloxetine decreases intermittent ethanol (EtOH) self-administration relative to pretreatment baseline. Graphs represent 24 h (daily) EtOH intake during the last of eight consecutive baseline weeks, followed by 4 week...

Duloxetine is a selective serotonin and norepinephrine reuptake inhibitor antidepressant. Duloxetine impacts chemicals in the brain that might be unbalanced in people with depression. Duloxetine is also used in adults to treat nerve pain triggered by diabetic issues, or chronic muscle or joint pain. People with depression or mental disease might have ideas about self-destruction. Some young people might have increased self-destructive thoughts when first starting a medicine to deal with depression. SNRIs are believed to work by raising the amount of mood-enhancing chemicals, serotonin and noradrenaline, in your brain. Duloxetine usually takes 2 to 4 weeks to work. If you and your doctor make a decision to take you off duloxetine, your doctor might advise minimizing your dose gradually to aid stop withdrawal symptoms. You may locate you can not concentrate properly while taking duloxetine. When you first begin taking it, it's a great suggestion to stop driving and biking, and stay clear of using machinery or tools, for the first couple of days up until you know how this medicine makes you really feel. The structural formula is: Duloxetine hydrochloride, USP is a beige to white colored crystalline powder which is freely soluble in methanol and moderately soluble in water. Each capsule has film-coated pellets of 22. 4, 33. 7, or 67. 3 mg of duloxetine hydrochloride, USP matching to 20, 30, or 60 mg of duloxetine, specifically. In enhancement, the 20 mg and 60 mg pills additionally consist of iron oxide yellow.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
60835C18H19NOS297.4CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32CNCC[[email protected]@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32InChI=1S/C18H19NOS/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16/h2-10,13,17,19H,11-12H2,1H3/t17-/m0/s1ZEUITGRIYCTCEM-KRWDZBQOSA-N(3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine4.3297.11873540297.1187354049.531201362101100001
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