Flucytosine

Summarized by Plex Health
Last Updated: 04 May 2022
evaluation of hepatotoxicity with treatment doses of flucytosine and amphotericin b for invasive fungal infections. "evaluation of hepatotoxicity with treatment doses of flucytosine and amphotericin b for invasive fungal infections.", by Folk A, Cotoraci C, Balta C, Suciu M, Herman H, Boldura OM, Dinescu S, Paiusan L, Ardelean A, Hermenean A. fig3: The effect of flucytosine and amphotericin B coadministration on the expression and specific hepatic distribution of TNF-α: (A) control group; (B) 50 mg/kg flucytosine + 300 μg/kg amphotericin B group; (C) 100 mg/kg flucytosine...

Flucytosine Capsules USP, an antifungal agent, is offered as 250 mg and 500 mg pills for oral administration. Along with the active ingredient of flucytosine USP, each pill has anhydrous lactose, jelly, iron oxide black, potassium hydroxide, potato starch, shellac, silicon talc, dioxide and titanium dioxide. On top of that, the 250 mg capsule covering consists of D&C yellow 10, FD&C blue 1 and FD&C yellow 6. Chemically, flucytosine is 5-fluorocytosine, a fluorinated pyrimidine which belongs to fluorouracil and floxuridine. It is a white or nearly white crystalline powder with a molecular weight of 129. 09 and the complying with structural formula: Flucytosine is often supplied another medicine called amphotericin B. Flucytosine might additionally be used for objectives not noted in this drug overview. Prior to you take flucytosine, inform your physician if you have kidney disease. It is not understood whether flucytosine will hurt an expected baby. If you are pregnant or strategy to become pregnant, tell your doctor. Flucytosine might cause nausea and vomiting. Your symptoms may enhance before the infection is completely removed. This medication works by eliminating the fungus or avoiding its growth. This medication is available only with your medical professional's prescription.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
3366C4H4FN3O129.09C1=NC(=O)NC(=C1F)NC1=NC(=O)NC(=C1F)NInChI=1S/C4H4FN3O/c5-2-1-7-4(9)8-3(2)6/h1H,(H3,6,7,8,9)XRECTZIEBJDKEO-UHFFFAOYSA-N6-amino-5-fluoro-1H-pyrimidin-2-one-0.9129.03383992129.0338399267.52080230900000001
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