Goldman

"the neurobiology of thought: the groundbreaking discoveries of patricia goldman-rakic 1937-2003.", by Arnsten AF. BHT195F8: The key role of dopamine in the primate dlPFC. (A) The dopaminergic innervation of the primate PFC, including the dlPFC area 46, as visualized using an antibody directed against dopamine. Note the relatively sparse...

Principal Investigator: Radoslav Goldman, Ph. D. Institution: Georgetown University, Washington, DC Subcontract Principal Investigator: Raja Mazumder, Ph. D. Institution: George Washington University PublicationsView magazines by Goldman. We are checking out site-specific protein glycoforms as a molecular trademark of hepatocellular cancer, the most common type of liver cancer. The occurrence of HCC increases in the United States primarily because of hepatitis C viral infection. HCV infection causes changes in glycosylation of liver produced proteins that can be adhered to along the progression of liver disease to HCC. This protein detects about 60% of HCC patients and its glycosylated type has a better uniqueness for the discovery of HCC. In this research, we are trying to find unique glycoforms of proteins that would enhance detection of liver diseases and HCC. We are enhancing analytical techniques for glycoprotein characterization with special rate of interest in metrology of the website specific protein glycoforms. In enhancement, we are taking a look at the connection of genomic variations affecting protein glycosylation with the advancement of hepatocellular cancer. When cancers are identified early, better treatment outcomes can be attained. We are exploring site-specific protein glycoforms as a molecular trademark of hepatocellular carcinoma, one of the most common type of liver cancer. The incidence of HCC has been boosting in the United States primarily as a result of liver disease C infection and increased occurrence of non-alcoholic steatohepatitis. HCV infection activates changes in glycosylation of proteins secreted by the liver that can be followed with the progression of liver disease to HCC. In our Alliance research, we are looking for unique glycoforms of liver-secreted proteins that will enhance discovery of liver diseases and HCC and develop clinically suitable LC-MS approaches for their quantification.

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