Holt-Oram syndrome is identified by skeletal abnormalities of the hands and arms and heart issues. People with Holt-Oram syndrome might have additional bone problems consisting of a missing thumb, a lengthy thumb that looks like a finger, partial or full lack of bones in the forearm, underdeveloped bone of the upper arm, and irregularities of the collar bone or shoulder blades. About 75 percent of people with Holt-Oram syndrome have heart issues, which can be lethal. An opening in the septum in between the top chambers of the heart is called an atrial septal issue, and an opening in the septum between the lower chambers of the heart is called a ventricular septal flaw. Some people with Holt-Oram syndrome have heart transmission disease, which is triggered by irregularities in the electrical system that works with contractions of the heart chambers. Cardiac transmission disease can occur in addition to other heart issues or as the only heart problem in people with Holt-Oram syndrome.
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