HYPOMYELINATION WITH brainstem and spinal cord involvement and leg spasticity

Summarized by Plex Health
Last Updated: 02 May 2022

Hypomyelination with brainstem and spinal cord involvement and leg spasticity is a condition that influences the brain and spinal cord. Particularly, the problem influences nerves in specific areas within the spinal cord and the brainstem, which is the part of the brain that attaches to the spinal cord. HBSL is a type of leukodystrophy, which is a group of problems that include abnormalities of the nerves's white matter. The white matter contains nerve fibers covered by a fatty substance, called myelin, that insulates the fibers and promotes the rapid transmission of nerve impulses. In HBSL, early growth of motor abilities may be normal, yet movement problems commonly start within the baby's first year. The particular feature of HBSL is muscle rigidity in the legs that gets worse gradually. Many people with HBSL are not able to walk separately. Distinct changes in the brains of people with HBSL can be seen using magnetic resonance imaging.

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