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Happens Insulin Levels Are High

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Last Updated: 02 July 2021

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One in three Americans, half of those aged 60 and older, have silent blood sugar problem known as insulin resistance. Insulin resistance increases the risk for prediabetes, type 2 Diabetes and a host of other serious health problems, including heart attacks, strokes 2 and cancer. 3 insulin resistance is when cells in your muscles, body fat and liver start resisting or ignoring signal that hormone insulin is trying to send outwhich, is to grab glucose out of your bloodstream and put it into your cells. Glucose, also know as blood sugar, is the body's main source of fuel. We get glucose from grains, fruit, vegetables, dairy products, and drinks that bring break down into carbohydrates. While genetics, aging and ethnicity play roles in developing insulin sensitivity, driving forces behind insulin resistance include excess body weight, too much belly fat, lack of exercise, smoking, and even skimping on sleep. 4 as insulin resistance develop, your body fights back by producing more insulin. Over months and years, beta cells in your pancreas that are working so hard to make insulin wear out and can no longer keep pace with demand for more and more insulin. Then - years after insulin resistance silently begins - your blood sugar may begin to rise and you may develop prediabetes or type 2 Diabetes. You may also develop non - alcoholic Fatty liver Disease, growing problem associated with insulin resistance that boosts your risk for liver damage and heart disease. 5 insulin resistance is usually triggered by a combination of factors linked to weight, age, genetics, being sedentary and smoking. - Large waist. Experts say the best way to tell whether youre at risk for insulin resistance involves tape measure and a moment of truth in front of the bathroom mirror. Waist that measures 35 inches or more for women, 40 or more for men 6 increases the odds of insulin resistance and metabolic syndrome, which is also linked to insulin resistance. - You have additional signs of metabolic syndrome. According to the National Institutes of Health, 7 in addition to large waist, if you have three or more of following, you likely have metabolic syndrome, which creates insulin resistance. High triglycerides. Levels of 150 or higher, or taking medication to treat high levels of these blood fats. Low HDLs. Low - density lipoprotein levels below 50 for women and 40 for men - or taking medication to raise low high - density lipoprotein levels. High blood pressure. Readings of 130 / 85 mmHg or higher, or taking medication to control high blood pressure and high blood sugar. Levels of 100 - 125 mg / dL or over 125. High fasting blood sugar. Mildly high blood sugar may be an early sign of Diabetes. - You develop dark skin patches. If insulin resistance is severe, you may have visible skin changes. These include patches of darkened skin on the back of your neck or on your elbows, knees, knuckles or armpits. This discoloration is called acanthosis nigricans.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

What is insulin?

The main actions that Insulin has are to allow glucose to enter cells to be used as energy and to maintain the amount of glucose found in the bloodstream within normal levels. Release of Insulin is tightly regulated in healthy people in order to balance food intake and metabolic needs of the body. This is a complex process and other hormones found in the gut and pancreas also contribute to this blood glucose regulation. When we eat food, glucose is absorbed from our gut into the bloodstream, raising blood glucose levels. This rise in blood glucose causes Insulin to be released from the pancreas so glucose can move inside cells and be used. As glucose moves inside cells, amount of glucose in the bloodstream returns to normal and Insulin release slows down. Proteins in food and other hormones produced by the gut in response to food also stimulate Insulin release. Hormones released in times of acute stress, such as adrenaline, stop release of Insulin, leading to higher blood glucose levels to help cope with stressful event. Insulin works in tandem with glucagon, another hormone produced by the pancreas. While Insulin's role is to lower blood sugar levels if needed, glucagon's role is to raise blood sugar levels if they fall too low. Using this system, body ensure that blood glucose levels remain within set limits, which allows the body to function properly.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

What is hyperinsulinemia?

Hyperinsulinemia may be diagnosed by testing your blood insulin and glucose levels. It may also be diagnosed by routine blood tests when undergoing testing for DIABETES or other conditions, such as high cholesterol. The primary test for assessing insulin levels is the insulin in blood test, which is a fasting test that involves taking a small sample of blood from the vein in your arm and assessing your insulin levels. Your healthcare provider will likely also request a fasting blood glucose test and possibly hemoglobin A1c to get a handle on your glycemic control, as well. Your insulin levels are considered normal if they re under 25 mIU / L during the fasting test. One hour after glucose administration, they may increase anywhere from 18 - 276 mIU / L. If your insulin levels are consistently this high or even more elevated, even when fasting, you could be diagnosed with hyperinsulinemia.


What are the causes?

The typical cause of hyperinsulinemia is insulin resistance. Insulin resistance is what happens when your body doesnt respond correctly to insulin. This incorrect response causes your body to need the pancreas to produce more insulin. As your pancreas makes more insulin, your body continues to resist and respond incorrectly to higher levels of insulin. Your pancreas will continually need to make more to compensate. Eventually, your pancreas wo be able to keep up with the amount of insulin your body needs to keep your blood sugar at a healthy level. Insulin resistance can eventually lead to type 2 diabetes. Less common causes of this condition are insulinoma and nesidioblastosis. Insulinoma is a rare tumor of pancreas cells that produce insulin. Nesidioblastosis is when the pancreas produces too many cells that make insulin. Hyperinsulinemia may also develop after having gastric bypass surgery. The theory is that cells have become too large and active for the body, but the body has changed significantly after bypass. Doctors are fully sure why this happen. Genetic predisposition, family history of hypertension, or high blood pressure


What are the treatment options?

A diet is particularly important in any treatment, as well as with the treatment of hyperinsulinemia. A healthy diet can help better regulate your body's overall functions and reduce excess weight. It may also help regulate your glucose and insulin levels. There are three preferred diets for glycemic control and treatment of hyperinsulinemia. They are: Mediterranean Diet, Low - Fat Diet, Low - carbohydrate Diet. These diets can help with your glycemic control, which will improve your body's insulin response. High - protein diets should be avoid. Diets high in protein may help with some forms of diabetes, but they can increase hyperinsulinemia. Each of these diets consists primarily of fruits, whole grains, vegetables, fiber, and lean meats. Be sure to discuss any diet changes with your doctor before beginning a new diet plan.


How is hyperinsulinemia caused?

Primary hyperinsulinemia causes hypoglycemia in infants and children and is the most common cause of hypoglycemia in neonates. Conditions are estimated to affect one in 50 000 newborns in US clinical presentation depending on age of child. Symptoms in infants may include sweating, lethargy, hypothermia, cyanosis, respiratory distress, irritability, jitteriness, seizures, tachycardia, poor feeding, and vomiting. In older children, symptoms may include anxiety, hunger, shakiness, sweating, increased appetite, lethargy, nausea, vomiting, lack of concentration, tachycardia, seizures, hypothermia, fainting, headache, and changes in behavior. Transient hyperinsulinemia is usually caused by factors such as birth asphyxia or maternal diabetes. However, if hyperinsulinemia persists, it may be due to a genetic defect that leads to increased insulin secretion.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Treatment and diet

Following a fixed diet plan, such as the Mediterranean Diet, can improve insulin sensitivity. The Mediterranean Diet involves eating lots of seasonal, plant - base foods, eating fruit for dessert, and using olive oil as the primary source of fat. People following this diet eat fish, poultry, legumes, and nuts as main protein choices and dairy products in moderation. Mediterranean eaters also limit their intake of red meat and consume little wine during meals. In a recent study, women who follow the Mediterranean Diet reduced their risk of cardiovascular health problems, including factors such as insulin resistance, by around 25 percent. People should base their daily calorie intake on their weight loss goals and body size. The Mediterranean Diet is just one option for healthy eating. Other diet plans, such as DASH and ketogenic Diets, also offer ways to improve insulin resistance. These work well when a person combines them with other healthy lifestyle practices, such as stress management, adequate sleep of 7 to 9 hours each night, and regular physical activity.


What is insulin resistance?

During doctor's visit, your doctor will ask you questions about your symptoms, your personal and family medical history, evaluate your weight, and take your blood pressure. Diagnosing insulin resistance requires a blood test. This might be done through small finger prick or by having a small needle inserted into the vein to take sample of blood. You will often be required to fast 8 hours before the test. Blood samples will be sent to the lab for testing. It will test your fasting blood sugar. Anything more than 100 mg / dL is an indication of insulin resistance. Your doctor also may have a lab test your cholesterol levels. People with insulin resistance often have high cholesterol. The American Academy of Family Physicians recommends blood glucose screening of all pregnant women for gestational diabetes after 24 weeks of pregnancy. Also, AAFP recommends blood glucose screening for adults aged 40 to 70 years who are overweight or obese and may be at risk of heart disease.


Foods to eat

However, people can still eat foods on this list occasionally without causing any long - term harm to their insulin sensitivity. The key is to limit these foods and replace them with more healthy options as often as possible. Sometimes, occasional treat can help person satisfy their sweet teeth and focus on adjusting their diet more regularly. By sticking to a high - fiber, plant - base diet that is low in added sugars, person can steadily improve their insulin sensitivity. Daily exercise is also a significant factor. During activity, muscles soak up glucose from the bloodstream and do not require insulin. Taking a walk after a meal and being active throughout the rest of the day can significantly improve blood sugar management. By losing 5 - 10 percent of their body weight, person can also significantly improve insulin sensitivity. These lifestyle changes can reduce the risk of type 2 diabetes, cardiovascular disease, and other health problems.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Risk factors

Researchers don't fully understand why some people develop prediabetes and type 2 diabetes and others do n't. It's clear that certain factors increase risk, however, including: weight. The more fatty tissue you have, more resistant your cells become to insulin. Inactivity. The less active you are, greater your risk. Physical activity helps you control your weight, uses glucose as energy and makes your cells more sensitive to insulin. Family history. Your risk increases if a parent or sibling has type 2 diabetes. Race or ethnicity. Although it's unclear why, certain people, including Black, Hispanic, American Indian and Asian American people, are at higher risk. Age. Your risk increases as you get older. This may be because you tend to exercise less, lose muscle mass and gain weight as you age. But type 2 diabetes is also increasing among children, adolescents and younger adults. Gestational diabetes. If you develop gestational diabetes when you are pregnant, your risk of developing prediabetes and type 2 diabetes later increases. If you give birth to a baby weighing more than 9 pounds, you are also at risk of type 2 diabetes. Polycystic ovary syndrome. For women, having polycystic ovary syndrome is a common condition characterized by irregular menstrual periods, excess hair growth and obesity increases risk of diabetes. High blood pressure. Having blood pressure over 140 / 90 millimeters of mercury is linked to an increased risk of type 2 diabetes. Abnormal cholesterol and triglyceride levels. If you have low levels of high - density lipoprotein, or good, cholesterol, your risk of type 2 diabetes is higher. Triglycerides are another type of fat carried in the blood. People with high levels of triglycerides have an increased risk of type 2 diabetes. Your doctor can let you know what your cholesterol and triglyceride levels are.


Symptoms

Diabetes symptoms vary depending on how much your blood sugar is elevate. Some people, especially those with prediabetes or type 2 diabetes, may not experience symptoms initially. In type 1 diabetes, symptoms tend to come on quickly and be more severe. Some of the signs and symptoms of type 1 and type 2 diabetes are: increased thirst Frequent urination Extreme hunger Unexplained weight loss Presence of ketones in urine, fatigue Irritability blur vision Slow - healing sores Frequent infections, such as gums or skin infections and vaginal infections Type 1 diabetes can develop at any age, though it often appear during childhood or adolescence. Type 2 diabetes, more common type, can develop at any age, though it's more common in people older than 40.


Causes

During digestion, your body breaks down carbohydrates from foods such as bread, rice and pasta into various sugar molecules. One of these sugar molecules is glucose, main energy source for your body. Glucose is absorbed directly into your bloodstream after you eat, but it can't enter cells of most of your tissues without the help of insulin hormone secreted by your pancreas. When the glucose level in your blood rises, it signals your pancreas to release insulin. Insulin unlocks your cells so that glucose can enter and provide fuel your cells need to function properly. Any extra glucose is stored in your liver and muscles in the form of glycogen. This process lowers the amount of glucose in your bloodstream and prevents it from reaching dangerously high levels. As your blood sugar level returns to normal, so does the secretion of insulin from your pancreas. Diabetes drastically lowers insulin's effects on your body. This may be because your pancreas is unable to produce insulin, or it may be because your body is resistant to the effects of insulin or doesn't produce enough insulin to maintain normal glucose level. As a result, glucose tends to build up in your bloodstream and may reach dangerously high levels if not treated properly. Insulin or other drugs are used to lower blood sugar levels.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Low-carb diets

Cardiovascular disease Insulin Resistance and hyperinsulinemia are associated with increased risks for cardiovascular disease, in part because they are so closely associated with other CVD risk factors such as obesity and hypertension. 28 Some studies suggest, however, that Insulin Resistance is an independent risk factor for heart disease. 29 There are a number of theories on why hyperinsulinemia could trigger progressive heart disease. Most of them center around increased chronic inflammation and oxidation as well as direct vascular damage. 30 Alzheimer's disease Recent evidence suggests that Alzheimer's disease could also be linked to Insulin Resistance. 31 Studies show that those with Diabetes are 60% more likely to develop dementia. 32 Another study shows an increased prevalence of brain degeneration in those with Diabetes. 33 Although the exact mechanism is not proven, theory is that brain cells become Insulin resistant and then cannot use Glucose efficiently for fuel, thus leaving cells starving for energy. The result is eventual progression to Alzheimer's disease. Adaptive Insulin Resistance Eating very - Low - carb Diets has been associated with development of Insulin Resistance. 34 However, some hypothesize that this is an adaptive physiologic response, and thus named adaptive or physiologic Insulin Resistance. 35 While this isnt proven, we can hypothesize that if we stop eating sugar or carbohydrates, amount of Glucose in our blood will fall. Our body will make sure, however, that our brain gets the glucose it needs by not taking up as much glucose in the liver, fat cells or muscle cells. The brain can then use a combination of glucose and ketones as fuel. 36 Muscle and liver cells instead use ketones almost exclusively for fuel. Since this type of Insulin Resistance occurs with low rather than high levels of circulating Insulin, it is not felt to represent the same dangerous condition as regular Insulin Resistance and may actually be a good thing. 37 You dont even need tape measure. Just take a piece of string! The length of string around your waist should be at most half your height. If your waist is larger than half your height, you likely have Insulin Resistance. One of the great strengths of this measurement is that your ethnicity doesnt matter, nor does it matter whether you are male or female, young or old, short or tall, muscular or wiry number higher than 0. 5 indicates increased risk. 40 many health campaigns are now encouraging this simple idea: keep your waist to less than half your height.


Diagnosing insulin resistance

Give prevalence of insulin resistance, how can one treat this common condition? Fda hasnt approved any drugs to specifically treat insulin resistance or pre - Diabetes. However, physicians may prescribe two classes of drugs normally used to treat type 2 Diabetes - biguanides and thiazolidinediones - which sensitize muscle cells, liver cells, and other tissues to the effects of insulin. That being say, best way to treat insulin resistance is to modify one's lifestyle behaviors. Weight - loss and exercise are considered to be the most effective methods in restoring the ability of tissues to properly respond to insulin. Interestingly, smoking contributes to insulin resistance, so many physicians recommend reducing or ceasing smoking altogether. In order to reduce insulin secretion, dietitians also recommend lowering carbohydrate intake. Provide that a ketogenic diet is an effective method in losing weight and lowering blood glucose, can it be used to lower insulin resistance and increase levels of insulin in the body? Below we document in - depth research.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

3. Watch Portion Sizes

Although the pancreas releases different amounts of insulin depending on the type of food you eat, eating too much of any food at one time can lead to hyperinsulinemia. This is especially concern for obese people with insulin resistance. In one study, insulin - resistant obese people who consumed 1 300 - calorie meal had twice the increase in insulin as lean people who consumed the same meal. They also experience nearly twice the increase in insulin as obese people who are considered metabolically healthy. Consuming fewer calories has consistently been shown to increase insulin sensitivity and decrease insulin levels in overweight and obese individuals, regardless of the type of diet they consume. One study looked at different weight loss methods in 157 people with metabolic syndrome. Researchers found that fasting insulin levels decreased by 16% in the group that practiced calorie restriction and 12% in the group that practiced portion control.


What is blood sugar?

Blood sugar, also know as blood glucose, comes from food you eat. Your body creates blood sugar by digesting some food into sugar that circulates in your bloodstream. Blood sugar is used for energy. Sugar that is n't needed to fuel your body right away gets stored in cells for later use. Too much sugar in your blood can be harmful. Type 2 diabetes is a disease that is characterized by having higher levels of blood sugar than what is considered within normal limits. Unmanaged diabetes can lead to problems with your heart, kidneys, eyes, and blood vessels. The more you know about how eating affects blood sugar, better you can protect yourself against diabetes. If you already have diabetes, it is important to know how eating affects blood sugar.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

5. Exercise Regularly

Comparison of responses during 40 min of moderate intensity exercise and 15 min of intense exercise in normal young male subjects. The rest period term baseline was followed by exercise of two different durations, as shown between vertical broken lines. The break in line for intense exercise is to permit plotting recovery period starting from cessation of exercise. Data is present as means SE.: Plasma glucose, unchanged in moderate and rising with intense exercise, especially in the recovery period. B: Plasma Insulin, with significant decline in moderate and trend downward in intense exercise, followed by marked rise in recovery. C: Plasma NE. D: Plasma EPI, both catecholamines increase about threefold in moderate, but markedly in intense exercise, with a rapid return to baseline levels. Comparison of responses during 40 min of moderate intensity exercise and 15 min of intense exercise in normal young male subjects. Data is presented as in Fig. 1.: Plasma Glucagon, showing no change in either intensity. B: Glucagon / Insulin molar ratio, showing slight rise during Exercise, with return to baseline in recovery after moderate intensity, and mark decline after high intensity Exercise. The latter is entirely due to postexercise hyperinsulinemia. C: Rate of GP. D: Rate of GU. Both GP and GU double in moderate exercise, whereas GP increases sevenfold and GU fourfold in intense exercise. Schematic representation of the current concept of glucoregulation during intense exercise. Feed - forward signal originating in the brain is viewed as causing increased sympathetic outflow that results in 14 - to 16 - fold increases in circulating EPI and NE. Solid arrows and their widths indicate increases in GP and GU; difference between their increments accounts for hyperglycemic response. Wide shade arrow indicate that at the same time that adrenergic stimulation of contracting muscle contributes to glycogenolysis, it restrains increase in GU from circulation. Plasma Insulin either declines minimally or remains constant during exercise, but increases rapidly and considerably postexercise period, mediated by hyperglycemia and release of adrenergic inhibition. Glucose turnover and Insulin in control and islet cell clamp studies with intense exercise in normal subjects. Before, during, and for 60 min following clamp, octreotide was infused simultaneously with basal infusions of Glucagon, Insulin, and growth hormone. Despite constant trihormonal infusion, increments of GP and GU are identical to control, as is Plasma glucose response. There is twofold increase in Plasma Insulin during exercise and no difference between studies in Glucagon, Yet GP response was unaffected. Effects of phentolamine infusion on metabolic responses to intense exercise in normal subjects. - Blockade markedly decreases Plasma glucose rise during and after intense Exercise, compared with that of controls, is associated with substantial rise in Insulin and attenuation of peak rise of GP. There was no effect on Glucagon or GU.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

What Is Diabetes?

Diabetes is a disease that affects how the body uses glucose, sugar that is the body's main source of fuel. Your body needs glucose to keep running. Here's how it should work: you eat. Glucose from food gets into your bloodstream. Your pancreas makes a hormone called insulin. Insulin helps glucose get into the body's cells. Your body gets energy it need.Sss Pancreas is a long, flat gland in your belly that helps your body digest food. It also makes insulin. Insulin is like a key that opens doors to cells of the body. It lets glucose IN. Then glucose can move out of the blood and into cells. But if someone has diabetes, either body can't make insulin or insulin doesn't work in the body like it should. Glucose can't get into cells normally, so blood sugar levels get too high. Lots of sugar in the blood makes people sick if they don't get treatment.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

What Is High Blood Sugar?

Managing diabetes is like a three - way balancing act because you have to watch: medicines you take, food that you eat, amount of exercise you get. All three need to be balance. If any one of these is off, blood sugar levels can be too. In general, higher than normal blood glucose levels can be caused by: not taking your diabetes medicine when you re supposed to or not taking the right amounts, not following a meal plan, not getting enough exercise, having illness, like flu stress, taking other kinds of medicines that affect how your diabetes medicines work single high blood sugar reading usually isn't cause for alarm it happen to everyone with diabetes from time to time. But if you have high blood sugar levels, let your parents and your diabetes health care team know. Insulin or meal plans may need adjusting, or you may have equipment issue, like an insulin pump that isn't working right. Whatever the case, make sure you get help so you can get your blood sugar levels back under control.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Sources

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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