Hereditary Sensory And Autonomic Neuropathy Type 1e

Summarized by Plex Health
Last Updated: 05 May 2022

Hereditary sensory and autonomic neuropathy type 1E is a rare congenital disease. HSAN1E is considered to be a subtype of HSAN, a group of genetic disorders most-ly influencing the autonomic and sensory neurons of the outer nervous system, the central nervous system is seriously affected in HSAN1E patients, particularly in the later phase of the disease. HSAN1E patients usually have three primary symptoms, hearing loss, sensory neu-ropathy, and cognitive decrease, and many have other different symptoms such as sleep disorders and epilepsy. HSAN1E is an autosomal leading congenital disease brought on by a mutation in the DNMT1 gene. Bilateral hearing loss is commonly the first symptom and it continues to become worse with time. Outer neuropathy happens when nerves that bring messages to and from the brain and spinal cord to the remainder of the body are harmed.

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