Hypochondrogenesis is uncommon, serious disorder of bone development. Bones in the skull develop normally, however the bones of the back and pelvis do not set effectively. People with hypochondrogenesis have a bigger abdominal area and may have a condition called hydrops fetalis in which excess fluid accumulates in the body before birth. As a result of these significant illness, some affected fetuses do not make it through to term. Infants born with hypochondrogenesis usually die at birth or quickly after that from respiratory failure. Babies who live past the newborn period are usually reclassified as having spondyloepiphyseal dysplasia congenita, a milder but relevant disorder that affects bone growth.
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