Isolated congenital asplenia is a condition in which affected people are missing their spleen yet have no other developing problems. While most people with this condition have no spleen in all, some people have a very small, nonfunctional spleen. The spleen generates specific immune system cells called phagocytes that assist get rid of microorganisms from the blood in order to avoid infections. The spleen also stores specific blood cells that combat foreign intruders until they are required and filters old blood cells for removal. They are very susceptible to bacterial infections due to the fact that people with isolated congenital asplenia lack these immune functions. People with isolated congenital asplenia are susceptible to developing severe, recurrent infections.
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