Idelalisib

Summarized by Plex Health
Last Updated: 02 May 2022
structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ. "structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ.", by Somoza JR, Koditek D, Villaseñor AG, Novikov N, Wong MH, Liclican A, Xing W, Lagpacan L, Wang R, Schultz BE, Papalia GA, Samuel D, Lad L, McGrath ME. F8: Comparison of apo PI3Kδ (Protein Data Bank accession code 2WXR) (A) and idelalisib-bound PI3Kδ showing the opening of the specificity pocket that accompanies idelalisib binding (B)....

Idelalisib is used together with rituximab to treat persistent lymphocytic leukemia, and certain types of lymphoma. Idelalisib is sometimes offered after at least 2 other cancer therapies did not have or work stopped working. Tell your physician at once if your everyday digestive tract movements increase by 6 or more. If you have ever before had a severe skin response to any medication, you may not be able to use idelalisib. Idelalisib can damage a coming infant if the dad or the mother is utilizing idelalisib. Your cancer treatments might be postponed based on the outcomes. Idelalisib is additionally being studied in the therapy of other types of cancer. Meaning from the NCI Drug Dictionary, Detailed scientific interpretation and other names for this drug. If they can help deal with or protect against conditions other than the ones they are accepted for, drugs are usually studied to discover out. This patient details sheet applies only to accepted uses of the drug. Much of the information might apply to unauthorized uses that are being researched. Targeted Cancer Therapies. Idelalisib hinders the growth of cancer cells, which are ultimately destroyed by the body. It is an antineoplastic agent. This medication is readily available only with your physician's prescription.

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PubChem - CovalentUnitCount

(Table source)
CIDMolecularFormulaMolecularWeightCanonicalSMILESIsomericSMILESInChIInChIKeyIUPACNameXLogPExactMassMonoisotopicMassTPSAComplexityChargeHBondDonorCountHBondAcceptorCountRotatableBondCountHeavyAtomCountIsotopeAtomCountAtomStereoCountDefinedAtomStereoCountUndefinedAtomStereoCountBondStereoCountDefinedBondStereoCountUndefinedBondStereoCountCovalentUnitCount
11625818C22H18FN7O415.4CCC(C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5CC[[email protected]@H](C1=NC2=C(C(=CC=C2)F)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5InChI=1S/C22H18FN7O/c1-2-15(28-20-18-19(25-11-24-18)26-12-27-20)21-29-16-10-6-9-14(23)17(16)22(31)30(21)13-7-4-3-5-8-13/h3-12,15H,2H2,1H3,(H2,24,25,26,27,28)/t15-/m0/s1IFSDAJWBUCMOAH-HNNXBMFYSA-N5-fluoro-3-phenyl-2-[(1S)-1-(7H-purin-6-ylamino)propyl]quinazolin-4-one3.7415.15568639415.1556863999.268502753101100001
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