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Kalipada Pahan

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Last Updated: 01 December 2020

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Kalipada Pahan

Born( 1964-02-19 ) 19 February 1964 (age 56) Midnapore , West Bengal , India
Known forResearch on statins (cholesterol-lowering drugs) and cinnamon
OccupationProfessor , Neuroscientist

Post January 7 2015 Kalipada Pahan, ph. D, Rush University Medical Center currently, there are no effective therapies available to treat Alzheimer's Disease despite intensive investigations. Although it is still unclear what causes Alzheimer's, researchers have identified a wide number of potential biological and lifestyle risk factors that contribute to the onset of the disease. The Peer review Alzheimer's Disease Research Program is investigating how well-know Alzheimer's Disease risk factors, when combined with traumatic brain injuries, produce long-term neurodegeneration. Dr. Kalipada Pahan, Floyd. Davis, Professor of Neurology at Rush University Medical Center, has been carefully studying mechanisms of neuro-inflammation in Alzheimer's Disease. Dr. Pahan believes that neuro-inflammation is a significant contributor to neurodegeneration caused by both Alzheimer's Disease and traumatic brain injuries. Understanding how disease works is important to developing effective drugs that protect the brain and stop progression of Alzheimer's Disease, say Kalipada Pahan, PhD. In an effort to develop novel therapeutic targets to treat Alzheimer's Disease, Dr. Pahan received funding in 2011 from PRARP to study mechanisms of microglial activation in Alzheimer's Disease. Normally, microglial cells secrete hormone-like compounds that promote neuron survival. In Alzheimer's Disease, hyper-activation of microglial cells results in neuro-inflammation and subsequent damage to neurons. Microglial cells are activated by protein fragment know as beta-amyloid, main component of amyloid plaques commonly found in the brains of Alzheimer's patients. Dr. Pahan and others believe beta-amyloid may play a significant role in neuro-inflammation. Therefore, plaques may be exacerbating the neuro-inflammatory response of microglial cells. The nuclear factor kappa B transcription factor is an important regulator of neuro-inflammation. Dr. Pahan and his team hypothesize that peptides which block specific binding domains important in NF-B activation would modulate neuro-inflammatory cascades and block further damage to neurons. After intranasal administration, peptide enters into brain, inhibits microglial activation, protects neurons, and improves memory and learning in mice with AD-like pathology, say Dr. Pahan. Using animal modeling, treatment with peptide improves cognitive function in animals predisposed to Alzheimer's Disease. In a separate study, Dr. Pahan showed that increased activation of NF-B in the cortex and hippocampus of Alzheimer's patients negatively affects cognitive function. Therefore, it is conceivable that these peptides may help Alzheimer's patients maintain or recover lose cognitive function.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Laboratory of Kalipada Pahan, PhD

The rationale of the laboratory of Kalipada Pahan, PhD, is both academic and therapeutic. From an academic angle, Pahan lab is trying to understand molecular mechanisms behind glial cell activation and neuronal death under various neuroinflammatory and neurogenerative conditions. While for therapeutic purposes, they are involved in discovering and / or repurposing drugs to suppress pathogenic mechanisms in multiple sclerosis, Parkinsons disease, Alzheimers disease, Batten disease, and HIV-associate neurocognitive disorders. Regulatory T cells are regarded as master regulators of immune responses because this cell type maintains homeostasis between immune activation and immune suppression. In autoimmune disorders such as multiple sclerosis, number of Tregs is reduce, leading to dysregulation of immune responses. Currently, Pahan lab is funded by a grant from NCCAM and a merit award from Veterans Affairs to investigate if and how cinnamon and aspirin upregulate Tregs to maintain immune homeostasis during autoimmune insults. Demyelination is another key aspect in MS, which is caused by loss of oligodendrocytes, myelin forming cells of the central nervous system. Fund by grant from NINDS, they will investigate if new group of physiological drugs protect oligodendrocytes and improve myelination in animal models of MS. Although the rate of disease progression varies from patient to patient, Parkinsons disease is a progressive neurodegenerative disorder. However, mechanism behind disease progression is poorly understood. Being funded by a grant from NINDS and a merit award from Veterans Affairs, they are targeting possible factors involved in progressive loss of dopamine in order to stop disease progression and improve locomotor function. One of the most common signs of Alzheimer's disease is memory loss and despite intense investigations, no effective therapy is available to improve memory in AD. Being funded by a grant from NIA, we are examining if our newly-identify hippocampal drugs stimulate neuronal plasticity, protect the hippocampus and improve memory and learning in animal models. They are also funded by other organizations, private foundations and biotech companies to work on other aspects of different neurological disorders.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

Kalipada Pahan, Ph.D.

Professor of Neurological Sciences, Biochemistry and Pharmacology Floyd. Davis, MD, endow Chair of Neurology Dr. Pahan was born in 1964, He received a BS in 1985, MS in 1987, and PhD in 1992 from the University of Calcutta, India. The same year, he joined the Department of Pediatrics, Medical University of South Carolina, as a postdoctoral fellow. In 1996, he was promoted to Instructor and later in 1998, he was promoted to Assistant Professor in the same Department. In 1999, he moved to the Department of Oral Biology of University of Nebraska Medical Center as Assistant Professor of Biochemistry where he was promoted to Associate Professor in 2002. He is the recipient of the D. H. Reinhardt Scholar Award from UNMC College of Dentistry and Silver U Award from the UNMC Chancellors Council. As teacher of Biochemistry, he received an outstanding teaching Award from UNMC College of Dentistry. He also received the Zenith Fellows Award from the Alzheimers Association. Additional information about Dr. Pahan is available on the Rush University website.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions.

* Please keep in mind that all text is machine-generated, we do not bear any responsibility, and you should always get advice from professionals before taking any actions

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