Lamivudine and zidovudine
Summarized by Plex Health
Last Updated: 02 May 2022
"evaluation of the activity of lamivudine and zidovudine against ebola virus", by . pone.0166318.g005: Antiviral activity of drug combinations against Makona variant of Ebola virus.Dose matrix (6 x 6) evaluation of two drug combinations, lamivudine/toremifene citrate and lamivudine/zidovudine. Huh 7 cells were pre-treated with drug combinations for 1...
Lamivudine and zidovudine tablets USP are combination tablets consisting of lamivudine and zidovudine. Lamivudine and zidovudine are synthetic nucleoside analogues with task against HIV-1. Lamivudine and zidovudine tablets USP are for oral administration. The chemical name of lamivudine is -4 amino-1 pyrimidin-2one. Lamivudine is the enantiomer of a dideoxy analogue of cytidine. It has the complying with structural formula: Lamivudine is a white to off-white strong with a solubility of about 68 mg/mL in water at 20 C. The chemical name of zidovudine is 3 -azido-3 -deoxythymidine. HIV can be passed to your child if the virus is not controlled while pregnant. Even if your infant is born without HIV, the virus might be passed to the infant in your breast milk. Use all HIV medications as routed and check out all drug guides you receive. If you've ever had hepatitis B, this virus may come to be active or get worse in the months after you stop utilizing lamivudine and zidovudine. HIV is the virus that causes obtained immune deficiency syndrome. This medicine helps keep HIV from replicating, and appears to reduce the damage of the immune system. This may assist delay the development of major health problems usually associated to AIDS or HIV infection. This medication is offered only with your medical professional's prescription.
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Sources:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3896c79b-8f02-4a77-bb80-e4aefc0de...
https://www.drugs.com/mtm/lamivudine-and-zidovudine.html
https://www.mayoclinic.org/drugs-supplements/lamivudine-and-zidovudine-oral-route/descript...
PubChem - CovalentUnitCount
(Table source)| CID | MolecularFormula | MolecularWeight | CanonicalSMILES | IsomericSMILES | InChI | InChIKey | IUPACName | XLogP | ExactMass | MonoisotopicMass | TPSA | Complexity | Charge | HBondDonorCount | HBondAcceptorCount | RotatableBondCount | HeavyAtomCount | IsotopeAtomCount | AtomStereoCount | DefinedAtomStereoCount | UndefinedAtomStereoCount | BondStereoCount | DefinedBondStereoCount | UndefinedBondStereoCount | CovalentUnitCount |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 160352 | C18H24N8O7S | 496.5 | CC1=CN(C(=O)NC1=O)C2CC(C(O2)CO)N=[N+]=[N-].C1C(OC(S1)CO)N2C=CC(=NC2=O)N | CC1=CN(C(=O)NC1=O)[[email protected]]2C[[email protected]@H]([[email protected]](O2)CO)N=[N+]=[N-].C1[[email protected]](O[[email protected]](S1)CO)N2C=CC(=NC2=O)N | InChI=1S/C10H13N5O4.C8H11N3O3S/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8;9-5-1-2-11(8(13)10-5)6-4-15-7(3-12)14-6/h3,6-8,16H,2,4H2,1H3,(H,12,17,18);1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7+,8+;6-,7+/m00/s1 | LHCOVOKZWQYODM-CPEOKENHSA-N | 4-amino-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one;1-[(2R,4S,5S)-4-azido-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione | 496.14886631 | 496.14886631 | 207 | 815 | 0 | 4 | 10 | 5 | 34 | 0 | 5 | 5 | 0 | 0 | 0 | 0 | 2 |
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